Camptothecin analogs and methods of preparation thereof

Details Camptothecin analogs and methods of preparation thereof Camptothecin analogs and methods of preparation thereof

2007-10-31

2010-02-02

Berch, Mark L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

C546S014000

Reexamination Certificate

active

07655640

ABSTRACT:
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt thereof:wherein R1and R2are independently the same or different and are hydrogen, an alkyl group, an aminoalkyl group, an alkylaminoalkyl group, a haloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkynyl group, an alkoxyl group, an aryloxy group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, —C(O)Rf, an amino group, an alkylamino group, a dialkylamino group, —SRc, or R1and R2together form a group of the formula —O(CH2)nO— wherein n represents the integer 1 or 2; R3is H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano group; or R2and R3 together form —O(CH2)nO— (n=1 or 2); R4is H, F, a C1-3alkyl group, a C2-3alkenyl group, a C2-3alkynyl group, or a C1-3alkoxyl group; R5is a C1-10alkyl group, or a propargyl group.

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