Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-01-05
2010-02-23
Kapushoc, Stephen (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100
Reexamination Certificate
active
07666599
ABSTRACT:
Aspects of the present invention provide novel compositions and methods based on novel calpastatin (CAST) genetic markers, such as missense mutations in exon 3 that result in G48D or P52L substitutions (NM_174003.2:c.271G>A and 283C>T), a G/T substitution in intron 3 (AAFC02060381.1:g.2110G>T) and a GAAA repeat in intron 8 (AAFC02060381.1:g.6700[(GAAA)4]+[(GAAA)5]. Particular aspects provide novel markers for fertility (e.g., daughter pregnancy rate, DPR) and longevity (e.g., productive life, PL) in, for example, dairy cattle. Additional aspects provide for novel methods comprising marker-assisted selection to improve fertility and/or longevity in dairy cattle. Therefore, in particular embodiments, a combination of genetic selection based on one or more of the novel CAST markers, and high PTA potentials of milk production traits, provides for improved reproductive traits in association with continued high milk production traits. Further aspects disclose a previously unrecognized XL domain in the human CAST gene, and thus provide for the use of human CAST XL domain mutants/variants as markers for human fertility and longevity.
REFERENCES:
patent: 2004/0115678 (2004-06-01), Barendse
patent: 2005/0059021 (2005-03-01), Farid et al.
patent: 2005/0065736 (2005-03-01), Bauck et al.
patent: 2005/0096458 (2005-05-01), Dumas Milne Edwards et al.
patent: 2005/0137805 (2005-06-01), Lewin et al.
patent: WO2006097787 (2006-09-01), None
Juppner H. Bone (1995) vol. 17, No. 2, pp. 39S-42S.
Hacker U.T. et al. Gut (1997) vol. 40, No. 5, pp. 623-627.
Parmely J.L. et al. BioEssays (2007) vol. 29, pp. 515-519.
Garcia M.D. ‘Mapping of Quantitative Trait Loci Associated with Fertility in Dairy Cattle’, (Dec. 2005) Doctor of Philosophy Dissertation, Washington State University, Department of Animal Sciences, 117 printed pages.
Tsuruta S. et al. J. Dairy Sci. (2005) vol. 88, pp. 1156-1165.
Ben-Aharon I, Ben-Yosef D, Amit A, Shaigi R. Expression and immunolocalization of the calpain-calpastatin system in the human oocyte. Fertil Steril 2005; 83:1807-1813.
Butler WR. Review: effect of protein nutrition on ovarian and uterine physiology in dairy cattle. J Dairy Sci. 1998; 81:2533-2539.
Cong M, Thompson VF, Goll DE, Antin PB. The bovine calpastatin gene promoter and a new N-terminal region of the protein are targets for cAMP-dependent protein kinase activity. J Biol Chem 1998; 273:660-666.
Kitahara A, Takano E, Ontsuki H, Kirihata Y, Yamagata Y, Knaagi R, Murachi T. Reversed distribution of calpains and calpastatin in human pituitary gland and selective localization of calpastatin in adrenocorticotropin-producing cells as demonstrated by immunohistochemistry. J Clin Endocrinol Metab 1986; 63:343-348.
Koide SS, Wang L, Kamada M. Antisperm antibodies associated with infertility : properties and encoding genes of target antigens. Proc Soc Exp Biol Med 2000; 224:123-132.
Li S, Goldberg E. A novel N-terminal domain directs membrane localization of mouse testis-specific calpastatin. Biol Reprod 2000; 63:1594-1600.
Li S, Liang ZG, Wang GY, Yavetz B, Kim ED, Goldberg E. Molecular cloning and characterization of functional domains of a human testis-specific isoform of calpastatin. Biol Reprod 2000; 63:172-178.
Liang ZG, O'Hern PA, Yavetz B, Yavetz H, Goldberg E. Human testis cDNAs identified by sera from infertile patients: a molecular biological approach to immunocontraceptive development. Reprod Fertil Dev 1994; 6:297-305.
Lucy MC. Reproductive loss in high-producing dairy cattle: where will it end? J Dairy Sci. 2001; 84:1277-1293.
Macmillan KL, Lean IJ, Westwood CT. The effects of lactation on the fertility of dairy cows. Aust Vet J 1996; 73:141-147.
Murachi T. Calpain and calpastatin. Rinsho Byori 1990; 38:337-346 (abstract only).
Orwig KE, Bertrand JE, Ou BR, Forsberg NE, Stormshak F. Involvement of protein kinase-C, calpains, and calpastatin in prostaglandin F2 alpha-induced oxytocin secretion from the bovine corpus luteum. Endocrinology 1994; 134:78-83.
Roche JF, Mackey D, Diskin MD. Reproductive management of postpartum cows. Anim Reprod Sci 2000; 61:703-712.
Royal MD, Darwash AO, Flint AP, Webb R, Woolliams JA, Lamming GE. Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility. Anim Sci 2000; 70:487-502.
Sheldon IM, Dobson H. Reproductive challenges facing the cattle industry at the beginning of the 21st century. Reprod Suppl. 2003; 61:1-13.
Thompson VF, Saldana S, Cong J, Luedke DM, Goll DE. The calpain system in human placenta. Life Sci 2002; 70:2493-508.
VanRaden PM, Sanders AH, Tooker ME, Miller RH, Norman HD, Kuhn MT, Wiggins GR. Development of a national genetic evaluation for cow fertility. Dairy Sci 2004; 87:2285-2292.
Wang LF, Miao SY, Yan YC, Li YH, Zong C, Koide SS. Expression of a sperm protein gene during spermatogenesis in mammalian testis: an in situ hybridization study. Mol Reprod Dev 1990; 26:1-5
Washburn SP, Silvia WJ, Brown CH, McDaniel BT, McAllister AJ. Trends in reproductive performance in Southeastern Holstein and Jersey DHI herds. J Dairy Sci. 2002; 85:244-251.
Wei SG, Wang LF, Miao SY, Zong SD, Koide SS. Expression of the calpastatin gene segment during spermiogenesis in human testis: an in situ hybridization study. Arch Androl 1995; 34:9-12.
Garcia Matthew D.
Jiang Zhihua
Michal Jennifer J.
Jarecki-Black Judy
Kapushoc Stephen
Kowalski, Esq. Thomas
Merial Limited
Washington State University Research Foundation
LandOfFree
Calpastatin markers for fertility and longevity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calpastatin markers for fertility and longevity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calpastatin markers for fertility and longevity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4208439