Calpain-inhibiting peptide analogs of the kininogen heavy chain

Details Calpain-inhibiting peptide analogs of the kininogen heavy chain Calpain-inhibiting peptide analogs of the kininogen heavy chain

1995-06-06

1998-06-23

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

514 13, 514 12, 530324, 530326, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

057706930

ABSTRACT:
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by inhibiting the activity of the biologically significant protease, calpain. The peptides are designed by means of an equilibrium conformational model of the kininogen heavy chain.

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Teno et al., Int. J. Peptide Protein Res., 30, 93-98 (1987).
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Puri et al., Trans. Assoc. Amer. Physicians, vol. CII, 13-19 (1989).
Ishiguru et al., Biochemistry, vol. 26, No. 28, 7021-7029 (1987).
Bradford et al., Biochemical Journal, vol. 270, No. 1, 83-90 (1990).
Higashiyama et al., Biochemistry, vol. 25, 1669-1675 (1986).

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