Calpain-inhibiting peptide analogs of the kininogen heavy chain

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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530324, 530327, 530328, 530329, 530330, 530325, A61K 3800, A61K 3802, C07K 500, C07K 700

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active

056632940

ABSTRACT:
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by inhibiting the activity of the biologically significant protease, calpain. The peptides are designed by means of an equilibrium conformational model of the kininogen heavy chain.

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Matsueda et al., Chem. Lett. 191-194 (Feb. 1990).
Puri et al., Trans. Assoc. Amer. Physicians 102, 13-19 (1990).

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