Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1995-02-07
1997-09-02
Davenport, Avis M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530324, 530327, 530328, 530329, 530330, 530325, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
056632940
ABSTRACT:
Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by inhibiting the activity of the biologically significant protease, calpain. The peptides are designed by means of an equilibrium conformational model of the kininogen heavy chain.
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Bradford Harlan N.
Colman Robert W.
Jameson Bradford A.
Davenport Avis M.
Temple University Of The Commonwealth System Of Higher Education
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