Caloxins

Details Caloxins Caloxins

2006-08-15

2006-08-15

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07091174

ABSTRACT:
Novel compound called caloxins which are extracellular plasma membrane (PM) Ca2+-pump inhibitors are described. One caloxin is caloxin 2A1 and has the amino acid sequence VSNSNWPSFPSSGGG. Another caloxin is caloxin 3A1 and has the amino acid sequence DSHINNEPSRRRGGGK. The caloxins are useful in inhibiting PM Ca2+-pumps and can be used in the development of treatments of various diseases including hypertension, hypotension, degenerative brain disorders, mood disorders, diabetes, kidney failure and cancer.

REFERENCES:
Chaudhary, J. et al. “Caloxin: a novel plasma membrane Ca2+ pump inhibitor,” American Journal of Physiology, 280(4 pt 1): C1027-C1030 (2001).
Kennedy B.G. and Mangini, N.J. “Plasma Membrane Calcium-ATPase in Cultured Human Retinal Pugment Epithelium,” Experimental Eye Research, 63: 547-556 (1996).
Enyedi, A. and Penniston, J.T. “Autoinhibitory Domains of Various Ca2+ Trasnporters Cross-react,” The Journal of Biological Chemistry, 268(23): 17120-17125 (1993).

Affiliated with

Also associated with

Rating

Caloxins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Caloxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Caloxins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3630050