Calmodulin binding peptide derivatives of non-erythroid alpha sp

Details Calmodulin binding peptide derivatives of non-erythroid alpha sp Calmodulin binding peptide derivatives of non-erythroid alpha sp

1989-03-02

1993-01-26

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 530324, 530325, 530326, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

051822628

ABSTRACT:
The present invention relates to a polypeptide and derivatives thereof deduced from the native structure of non-erythroid alpha spectrin and compositions thereof. One embodiment of the invention is 24 amino acids in length and composed of the following linear sequence of residues: Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu- Met-Val-His-Thr-Val-Ala-Thr-Phe-Asn-Ser-Ile-Lys-Glu. The invention further relates to methods of using the polypeptide, such as methods for treating disorders including prophylaxis against organ and tissue transplant rejection or treatment of autoimmune disorders.

REFERENCES:
Speicher et al., Nature, vol. 311, 1984, pp. 177-180.
Glenney et al., Proc. Natl. Acad. Sci., vol. 79, 1982, pp. 4002-4005.
Leto et al., Mol. Cell Biol., vol. 8, No. 1, 1988, pp. 1-9.
Sahr et al., J. Biol. Chem., vol. 265, No. 8, 1990, pp. 4434-4443.
Leto et al., Biol. Abstr., vol. 87 (12), Rf. No. 122170.
Moon et al., J. Biol. Chem., vol. 265, No. 8, 1990, pp. 4427-4433.
Birkenmeier et al., Proc. Natl. Acad. Sci., vol. 82, 1985, pp. 5671-5675.

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