Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-02-23
1996-06-18
Naff, David M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435126, 435156, 43524054, C12N 500, C12P 1704
Patent
active
055277020
ABSTRACT:
A method for the induction of callus cells capable of producing taxanes from explant tissue by partially submerging the explant tissue in a liquid culture medium on a membrane raft, resulting in callus formation. The induction of callus cells by this method provides direct transfer of the cells formed to a liquid medium for a suspension cell culture preparation of taxanes. Thus, there is no need of a separate growth or proliferation step in the method of this invention. Furthermore, callus cells can be produced by the method; and also disclosed is a method for the use of the callus cells so produced in a suspension cell culture preparation for taxanes.
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Cazzulino Dana L.
Cino Paul M.
Schwarz Steven R.
Babajko Suzanne E.
E. R. Squibb & Sons Inc.
Naff David M.
Ware Deborah K.
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