Calixarene chloride-channel blockers

Details Calixarene chloride-channel blockers Calixarene chloride-channel blockers

1994-01-07

1996-02-06

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514577, 514618, 514709, A61K 3119, A61K 31185, A61K 31165, A61K 3110

Patent

active

054896126

ABSTRACT:
Calixarene derivatives, their synthesis and use as chloride channel blockers are described. Preferred calixarene derivatives are of the formula: ##STR1## wherein R is an acidic group or salt thereof, such as SO.sub.3 X or R.sup.1 SO.sub.3 X where X is H or Na, and R.sup.1 is ##STR2## where m=1-2, and R.sup.3 and R.sup.4 the same or different is each H or a C.sub.1-4 alkyl, or a nitrogen-containing group of the formula ##STR3## or A, wherein R.sup.5 is a C.sub.1-4 alkyl, R.sup.6 is a C.sub.1-4 alkyl and A is ##STR4## where R.sup.7 and R.sup.8, the same or different each is H or a C.sub.1-4 alkyl, and R.sup.9 and R.sup.10, the same or different, each is H or a C.sub.1-4 alkyl; R' is H or a C.sub.1-4 alkyl; and n is an integer of 4-8, preferably 4, 6 or 8.

REFERENCES:
patent: 4617336 (1986-10-01), Pastor et al.
patent: 5206437 (1993-04-01), Morita
patent: 5312837 (1994-05-01), Hwang et al.
Mahendra Kumar et al., Biochem. J. (1985) 227 789-794.

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