Calicheamicin mimics

Details Calicheamicin mimics Calicheamicin mimics

1994-09-07

1996-08-27

Conrad, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 20, 560107, C07D21304

Patent

active

055502466

ABSTRACT:
Synthetic calicheamicin mimics employ alternative activation triggers and trigger cites and include tithers for conjugation to DNA targeting systems.

REFERENCES:
patent: 5264586 (1993-11-01), Nicolaou et al.
Nicolaou, et al., "Cell-Specific Regulation of Apoptosis by Designed Enediynes", Proc. Natl. Acad. Sci, 90: 3142-3146 (1993).
Nicolaou, et al., "Chemistry and Biology of Natural and Designed Enediynes", Proc. Natl. Acad. Sci., 90: 5881-5888 (1993).
Nicolaou, et al., "Designed Enediynes: A New Class of DNA-Cleaving Molecules with Potent and Selective Anti Cancer Activity", Science, 256: 1172-1178 (1992).
Nicolaou, et al., "Total Synthesis of Calicheamicin", J. Am. Chem. Soc., 114: 10082-10084 (1992).
Danishefsky, et al., "A Convergent Total Synthesis of Calicheamicin v", Angew. Chem. Int. Ed., 33: 858-862 (1994).
Danishefsky, et al., "On the DNA Recognition Role of the Carbohydrate Sector in Calicheamicin: A Comparison of DNA Cleaving Capacity of Enantiomeric Calicheamicinones", Angew. Chem. Int. Ed., 33: 855-857 (1994) .

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