Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Blood serum or blood plasma standard or control
Patent
1995-11-07
1998-05-19
Le, Long V.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Blood serum or blood plasma standard or control
436 8, 436 15, 436 17, 436 69, C12Q 156, G01N 3386, G01N 3396
Patent
active
057535108
ABSTRACT:
The invention relates to a plasma which can be used as a calibrator in coagulation tests which detect the degradation of factor V by activated protein C, to the preparation of such a plasma and to its use.
REFERENCES:
patent: 5221614 (1993-06-01), Enomoto
patent: 5387503 (1995-02-01), Selmer et al.
Esmon, "Protein S and Protein C Biochemistry, Physiology, and Clinical Manifestation of Deficiencies", Trends Cardiovasc Med., 2(6):214-219 (1992).
Rick, et al., "Factor IXa and von Willebrand factor modify the inactivation of factor VII by activated protein C", J. Lab Clin Med., 115(4):415-421 (1990).
Amer, et al., "Impairment Of the Protein C Anticoaqulant Pathway In A Patient With Systemic Lupus Erthematosus, Anticardiolipin Antibodies and Thrombosis", Thrombosis Research, 57 (2):247-258 (1990).
Bertina, et al., "Mutation in blood coagulation factor V associated with resistance to activated protein C", Nature, 369:64-67 (1994).
Karges, et al., "Activity of Coaqulation and Fibrinolysis Parameters in Animals", Arzneimittel-Forschung Drug Research, 44 (I), 6,:793-797 (1994).
Bertina et al., "Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C," Nature 369:64-67 (1994).
Karges et al., "Activity of Coagulation and Fibrinolysis Parameters in Animals," Arzneim.-Forsch/Drug Res. 44(1) (6):793-97 (1994).
Kraus et al., "Coagulation Assay with Improved Specificity to Factor V Mutants Insensitive to Activated Protein C," Thrombosis Res. 80(3):255-64 (1994).
Behring Diagnostics GmbH
Le Long V.
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