Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2006-07-04
2006-07-04
Lee, John R. (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S287000, C250S281000
Reexamination Certificate
active
07071463
ABSTRACT:
In its most general terms the invention compensates for the effect of the mass offset in the prior art calibration method. This can be achieved either by correcting for the offset or assigning mass to the peaks in such a way that the offset is avoided. Accordingly in a first aspect there is provided a method of calibrating a reflectron time-of-flight mass spectrometer using a spectrum generated by fragment ions wherein a measured mass value is modified to take account of the effect of post source decay and that modified value is used for calibration. A modified calibration function can then be defined and used to determine actual fragment ion masses of an unknown compound.
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Kratos Analytical Limited
Lee John R.
Squire Sanders & Dempsey LLP
Vanore David A.
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