Calibrated spectrographic imaging

Details Calibrated spectrographic imaging Calibrated spectrographic imaging

1992-07-24

1995-09-26

Smith, Ruth S.

Surgery

Truss

Pad

128665, 25033901, 250340, 356318, 356326, A61B 600

Patent

active

054527236

ABSTRACT:
The present application is directed to the use of photon migration analysis to provide a method of analyzing the diffuse reflectance, fluorescence, Raman or other types of spectra obtained from tissue. This procedure provides a means for processing spectral data such that the distortion in fluorescence spectra, for example, caused by the interplay of a variety of factors such as scattering, absorption, geometry and boundary conditions, can be precisely removed simply by measuring the diffuse reflectance spectrum as well as a second selected spectrum, such as fluorescence, and adjust the spectrum with the reflectance spectrum as described herein. By this procedure, the sample-to-sample variability is minimized. The intrinsic spectrum extracted by this procedure can be easily deconvoluted and provide quantitative information about the physicochemical composition of tissue. Analytical procedures for clinical diagnosis have been developed based on this method.

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