Chemistry: analytical and immunological testing – Involving iga – igd – ige – or igm
Patent
1983-04-08
1985-12-10
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving iga, igd, ige, or igm
436535, 436804, 436805, 436806, 436807, 436808, 436809, 435 4, 435 7, 422 56, 422 57, 422 58, 422 61, 422 68, 422 71, G01N 3358, G01N 2100
Patent
active
045580138
ABSTRACT:
Method and apparatus for use in accurately measuring the binding reactions occurring between a predetermined class of components in a liquid specimen and their corresponding binding conjugates coated on separate test regions of a carrier. The carrier further includes a reference region that is uncoated, and the carrier is adapted for simultaneous contact of all of its regions with the liquid specimen. Any resulting binding reaction on each test region indicates both specific binding to the coated component as well as non-specific binding, and any resulting binding reaction on the reference region indicates merely non-specific binding. The measurements for the test regions are all reduced by an amount determined in accordance with the measurement for the reference region, to reduce the effects of non-specific binding on those measurements and thereby provide accurate measurements of the specific binding on each coated component.
REFERENCES:
patent: 3941876 (1976-03-01), Marinkovich
patent: 4031197 (1977-06-01), Marinkovich
patent: 4211762 (1980-07-01), Huggins et al.
patent: 4235865 (1980-11-01), Thoma
patent: 4256833 (1981-03-01), Ali et al.
patent: 4331650 (1982-05-01), Brewer et al.
patent: 4459360 (1984-07-01), Marinkovich
patent: 4486540 (1984-12-01), Brewer et al.
Dyminski John W.
Marinkovich Vincent A.
Riege David H.
Mast Immunosystems Ltd.
Nucker Christine M.
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