Calcium supplementation by dicalcium citrate-lactate

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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514574, C07C 5500, A61K 3119

Patent

active

050754998

ABSTRACT:
One aspect of the present invention includes the novel compound having the formula:

REFERENCES:
McCarron et al., Dietary Calcium in Human Hypertension, Science, vol. 217, Jul. 16, 1982, pp. 267-269.
McCarron, Low Serum Concentrations of Ionized Calcium in Patients with Hypertension, The New England Journal of Medicine, vol. 307, No. 4, Jul. 22, 1982, pp. 226-228.
Ackley et al., Dairy Products, Calcium, and Blood Pressure, The American Journal of Clinical Nutrition, vol. 38, Sep. 1983, pp. 457-461.
Belizan et al., Reduction of Blood Pressure with Calcium Supplementation in Young Adults, JAMA, vol. 249, No. 9, Mar. 4, 1983, pp. 1161-1165.
Belizan et al., Preliminary Evidence of the Effect of Calcium Supplementation on Blood Pressure in Normal Pregnant Women, Am. J. Obstet, Gynecol., vol. 146, No. 2, May 15, 1983, pp. 175-180.
Nordin et al., Treatment of Spinal Osteoporosis in Postmenopausal Women, British Medical Journal, Feb. 16, 1980, pp. 451-454.
Recker et al., Effect of Estrogens and Calcium Carbonate on Bone Loss in Postmenopausal Women, Annals of Internal Medicine, vol. 87, No. 5, Dec. 1977, pp. 649-655.
Harvey et al., Calcium Citrate: Reduced Propensity for the Crystallization of Calcium Oxalate in Urine Resulting from Induced Hypercalciuria of Calcium Supplementation, Journal of Clinical Endocrinology and Metabolism, vol. 61, No. 6, Jul. 85, pp. 1223-1225.
Pak, Bioavailability and Clinical Uses of Calcium Salts, CRN Quarterly, 1988, vol. 12, No. 3, pp. 8-10.
Pak et al., Enhanced Calcium Bioavailability from a Solubilized Form of Calcium Citrate, Journal of Clinical Endocrinology and Metabolism, vol. 65, No. 4, 1987, pp. 801-805.
Harvey et al., Dose Dependency of Calcium Absorption: A Comparison of Calcium Carbonate and Calcium Citrate, Journal of Bone and Mineral Research, vol. 3, No. 3, 1988, pp. 253-258.
Chem. Abstracts, 75(10):67476 (1971), Rosenthaler et al.

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