Chemistry: analytical and immunological testing – Metal or metal containing – Present in biological fluids
Patent
1996-08-15
1998-05-05
Soderquist, Arlen
Chemistry: analytical and immunological testing
Metal or metal containing
Present in biological fluids
422 56, 422 57, 422 58, 436 73, 436 79, 436164, 436166, 436169, 534670, 534751, 534770, 534797, 534816, 534831, G01N 3320
Patent
active
057473455
ABSTRACT:
Diaza-18-crown-6 compounds of the formula I: ##STR1## wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from hydrogen, halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are hydrogen and X is phenol, R.sub.4 is not nitro; and provided that when X is phenol and R.sub.5 is hydrogen, R.sub.1 (or R.sub.2) and R.sub.4 are not both nitro. Compounds of the above formula are useful as chromoionophores for the detection of calcium ions in solution or dry assays, but are of particular advantage when used in dry, thin-film multilayer analytical elements.
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Logan Margaret Elizabeth
Messing Calvin Roman
Weber, II Wayne Woodrow
Dow Kenneth J.
Johnson & Johnson Clinical Diagnostics Inc.
Soderquist Arlen
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