Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2008-05-30
2010-06-29
Marschel, Ardin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
Reexamination Certificate
active
07745423
ABSTRACT:
The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
REFERENCES:
patent: 4192869 (1980-03-01), Nicolau et al.
patent: 4321259 (1982-03-01), Nicolau et al.
patent: 4404150 (1983-09-01), Tsunekawa et al.
patent: 4473496 (1984-09-01), Scannon
patent: 4478824 (1984-10-01), Franco et al.
patent: 4650786 (1987-03-01), Wong
patent: 4652449 (1987-03-01), Ropars et al.
patent: 4699926 (1987-10-01), Abraham et al.
patent: 4710488 (1987-12-01), Wong
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4731473 (1988-03-01), Abraham et al.
patent: 4735936 (1988-04-01), Sirén
patent: 4751244 (1988-06-01), Abraham et al.
patent: 4752586 (1988-06-01), Ropars et al.
patent: 4777134 (1988-10-01), Siren
patent: 4794014 (1988-12-01), Siren
patent: 4797390 (1989-01-01), Siren
patent: 4826675 (1989-05-01), Gaffar et al.
patent: 4847082 (1989-07-01), Sabin
patent: 4851560 (1989-07-01), Siren
patent: 4873355 (1989-10-01), Hobbs et al.
patent: 4874690 (1989-10-01), Goodrich, Jr. et al.
patent: 4887995 (1989-12-01), Abraham et al.
patent: 4924023 (1990-05-01), Hobbs et al.
patent: 4931276 (1990-06-01), Franco et al.
patent: 4952396 (1990-08-01), Sabin et al.
patent: 4952717 (1990-08-01), Ozaki et al.
patent: 5003098 (1991-03-01), Siren et al.
patent: 5015634 (1991-05-01), Siren
patent: 5019566 (1991-05-01), Siren
patent: 5023248 (1991-06-01), Siren
patent: 5043261 (1991-08-01), Goodrich et al.
patent: 5051411 (1991-09-01), Siren
patent: 5057507 (1991-10-01), Siren
patent: 5082833 (1992-01-01), Shamsuddin
patent: 5091549 (1992-02-01), Ozaki et al.
patent: 5135923 (1992-08-01), Siren
patent: 5151539 (1992-09-01), Bright et al.
patent: 5210263 (1993-05-01), Kozikowski et al.
patent: 5252707 (1993-10-01), Ozaki et al.
patent: 5260287 (1993-11-01), Barreto et al.
patent: 5260472 (1993-11-01), Chen
patent: 5264605 (1993-11-01), Ozaki et al.
patent: 5274161 (1993-12-01), Siren et al.
patent: 5292913 (1994-03-01), Ozaki et al.
patent: 5295944 (1994-03-01), Teicher et al.
patent: 5296466 (1994-03-01), Kilbourn et al.
patent: 5330979 (1994-07-01), Siren et al.
patent: 5344393 (1994-09-01), Roth et al.
patent: 5407924 (1995-04-01), Siren
patent: 5428007 (1995-06-01), Fischer et al.
patent: 5451205 (1995-09-01), Roth et al.
patent: 5545632 (1996-08-01), Siren
patent: 5612207 (1997-03-01), Nicolau et al.
patent: 5626884 (1997-05-01), Lockett
patent: 5720921 (1998-02-01), Meserol
patent: 5827837 (1998-10-01), Bevilacqua et al.
patent: 5846957 (1998-12-01), Siren
patent: 5866548 (1999-02-01), Tsien et al.
patent: 5866557 (1999-02-01), Persson et al.
patent: 5880099 (1999-03-01), Traynor-Kaplan et al.
patent: 5977078 (1999-11-01), Traynor-Kaplan et al.
patent: 6004938 (1999-12-01), Frick et al.
patent: 6074605 (2000-06-01), Meserol et al.
patent: 6096916 (2000-08-01), Aneja
patent: 6187335 (2001-02-01), Brey et al.
patent: 6610702 (2003-08-01), Lehn et al.
patent: 7084115 (2006-08-01), Nicolau et al.
patent: 7084126 (2006-08-01), Frey, II et al.
patent: 2002/0028786 (2002-03-01), Frey, II et al.
patent: 2002/0142995 (2002-10-01), Nicolau et al.
patent: 2002/0173494 (2002-11-01), Lehn et al.
patent: 2003/0017150 (2003-01-01), Torphy
patent: 2003/0147937 (2003-08-01), Schwarz
patent: 2004/0014642 (2004-01-01), Nicolau et al.
patent: 2004/0072801 (2004-04-01), Nicolau et al.
patent: 2004/0147487 (2004-07-01), Traylor-Kaplan et al.
patent: 2005/0020542 (2005-01-01), Traynor-Kaplan et al.
patent: 2005/0227946 (2005-10-01), Siren
patent: 2005/0250743 (2005-11-01), Lehn et al.
patent: 2005/0272642 (2005-12-01), Frey, II et al.
patent: 2006/0009413 (2006-01-01), Frey, II et al.
patent: 2006/0014716 (2006-01-01), Frey, II et al.
patent: 2006/0030542 (2006-02-01), Frey, II et al.
patent: 2006/0106000 (2006-05-01), Nicolau et al.
patent: 2006/0116358 (2006-06-01), Nicolau et al.
patent: 2006/0241086 (2006-10-01), Nicolau et al.
patent: 2006/0258626 (2006-11-01), Nicolau et al.
patent: 2007/0066574 (2007-03-01), Grases Freixedas
patent: 2007/0129336 (2007-06-01), Traynor-Kaplan
patent: 2007/0135389 (2007-06-01), Nicolau et al.
patent: 2007/0207986 (2007-09-01), Nicolau et al.
patent: 0 392 697 (1990-10-01), None
patent: 0 508 488 (1992-10-01), None
patent: 52-107239 (1977-09-01), None
patent: 1-175989 (1989-07-01), None
patent: WO 87/05598 (1987-09-01), None
patent: WO 92/20369 (1992-11-01), None
patent: WO 94/21117 (1994-09-01), None
patent: WO 95/03068 (1995-02-01), None
patent: WO 95/05830 (1995-03-01), None
patent: WO 96/32136 (1996-10-01), None
patent: WO 01/013933 (2001-03-01), None
patent: WO 01/15738 (2001-03-01), None
patent: WO 01/24830 (2001-04-01), None
patent: WO 01/82932 (2001-11-01), None
patent: WO 02/09723 (2002-02-01), None
patent: WO 02/10177 (2002-02-01), None
patent: WO 03/092700 (2003-11-01), None
patent: WO 2006/102060 (2006-09-01), None
Kobayashi et al, “Oxygenation of Hypoxic Region in Solid Tumor by Administration of Human Serum Albumin Incorporating Synthetic Hemes”. J Biomed Mater Res; 64A:2003; 48-51.
Fylaktakidou et al. “Inositol Tripyrophosphate: A New Membrane Permeant Allosteric Effector of Haemoglobin”. Bioorganic and Medicinal Chemistry Letters; 15(2005):1605-1608.
Title: EntreMed Annual Report, Publ:EDGAR Online, pp. 1-40, Date: Mar. 3, 2000.
Author: Adachi et al., Title: Nucleation-Controlled Aggregation of Deoxyhemoglobins—Effect of Organic Phosphates on the Kinetics of Aggregation of DeoxyhemoglobinS in Concentrated Phosphate Buffer, Publ:Biochimica et Biophysica Acta, vol./Iss: 624, pp. 372-377, Date: Aug. 21, 1980.
Author: Amorino et al., Title: Enhancement of Tumor Oxygenation and Radiation Response by the Allosteric Effector of Hemoglobin, RSR13, Publ:Radiation Research, vol./Iss: 156, pp. 1, Date: Oct. 12, 2000.
Author: Arnone, A., Title: X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin, Publ:Nature, vol./Iss: 237 (5350), pp. 146-149, Date: May 12, 1972.
Author: Benesch et al., Title: The Effect of Organic Phosphates from the Human Erythrocyte on the Allosteric Properties of Hemoglobin, Publ:Biochemical and Biophysical Research Communications, vol./Iss: 26 (2), pp. 162-167, Date: Jan. 23, 1967.
Author: Benesch et al., Title: Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin, Publ:Nature, vol./Iss: 221, pp. 618-622, Date: Feb. 15, 1969.
Author: Cosgrove, D.J., Title: The Phosphorylation ofepi-Inositol andmuco-Inositol with Polyphosphoric Acid, Publ:Carbohydrate Research, vol./Iss: 40, pp. 380-384, Date: Jan. 1, 1975.
Author: Desai et al., Title: The Preparation, Resolution, and Phosphorylation of Some Benzyl Ethers ofmyo-Inositol: Intermediates for the Synthesis ofmyo-Inositol Phosphates of the Phosphotidylinositol Cycle, Publ:Carbohydrate Research, vol./Iss: 225, pp. 209-228, Date: Mar. 1, 1992.
Author: Dinkel et al., Title: Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives, Publ:Angewandte Chemie International Edition, vol./Iss: 40 (16), pp. 3004-3008, Date: Aug. 17, 2001.
Author: Fisher, J., Title: Erythropoietin: Physiology and Pharmacology Update, Publ:Society for Experimental Biology and Medicines, vol./Iss: 228(1), pp. 1-14, Date: Jan. 1, 2003.
Author: Fylaktakidou et al., Title: Inositol Triphosphate: A New Membrane Permeant Allosteric Effector of Haemoglobin, Publ:Bioorganic&Medicinal Chemistry Letters, vol./Iss: 15, pp. 1605-1608, Date:Jan. 1, 2005.
Author: Gersonde et al., Title: Modification of the Oxygen Affinityof Intracellular Haemoglobin by Incorporation of Polyphosphates into Intact Red Blood Cells and Enhanced O2Release in theCapillary System, Publ:Bibliotheca Haematologica, vol./Iss: 46, pp. 81-92, Date: Sep. 1,
Fylaktakidou Konstantina C.
Greferath Ruth
Lehn Jean-Marie
Nicolau Yves Claude
Marschel Ardin
NormOxys, Inc
Ropes & Gray LLP
Royds Leslie A
Universite de Strasbourg
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