Calcium salts with cytotoxic activity

Details Calcium salts with cytotoxic activity Calcium salts with cytotoxic activity

2002-07-01

2008-09-09

Marschel, Ardin H. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

Reexamination Certificate

active

07423063

ABSTRACT:
Calcium salts, in particular calcium trifluoroacetate, are added to medicaments to provide cytotoxic and antitumoral activity. The medicaments can be administered to cancer patients as part of a method of treating a cancer patient. The medicaments can also be applied to a tumor to treat the tumor. The medicaments may be administered or applied orally or parenterally.

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Webb, T.E. et al.:, “Pharmacokinetics relevant to the anticarcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate: retinoid in the rat” Biochemical Pharmacology, vol. 47, No. 9, 1994, pp. 1655-1660, XP008009071 abstract.
Dwivedi, CH. et al.:, “Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate”, Journal of Environmental Pathology, Toxicological Oncology, vol. 9, No. 3, 1989, pp. 253-259, XP008009073, abstract.

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