Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-06-07
1998-06-09
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530300, 530376, 530327, 530329, 530350, 536 231, 536 235, 435 71, 435 691, 4352523, 4353201, C07K 14705
Patent
active
057635692
ABSTRACT:
The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.
REFERENCES:
patent: 3262977 (1966-07-01), Harsanyi et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3862925 (1975-01-01), Sarantakis
patent: 3972859 (1976-08-01), Fujino et al.
patent: 4000197 (1976-12-01), Barfknecht et al.
patent: 4105602 (1978-08-01), Colescott et al.
patent: 4391826 (1983-07-01), Mills et al.
patent: 4587253 (1986-05-01), Halczenko et al.
patent: 4609494 (1986-09-01), Baldwin
patent: 4675321 (1987-06-01), Baldwin
patent: 4677101 (1987-06-01), Claremon et al.
patent: 4728660 (1988-03-01), Haynes et al.
patent: 4808718 (1989-02-01), Hartman et al.
patent: 4839369 (1989-06-01), Youssefyeh et al.
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4925873 (1990-05-01), Friedhoff
patent: 4945050 (1990-07-01), Sanford et al.
patent: 4967003 (1990-10-01), Rentzea et al.
patent: 4987071 (1991-01-01), Cech et al.
patent: 4988730 (1991-01-01), Korbonits et al.
patent: 4992378 (1991-02-01), Kelly et al.
patent: 5011834 (1991-04-01), Weber et al.
patent: 5021599 (1991-06-01), Beer et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5034514 (1991-07-01), Nitecki et al.
patent: 5045466 (1991-09-01), Morrison
patent: 5053337 (1991-10-01), Weinshank et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5082837 (1992-01-01), Palfreyman et al.
Abe et al., "Molecular Characterization of a Novel Metabotropic Glutamate Receptor mGluR5 Coupled to Inositol Phosphate/Ca.sup.2+ Signal Transduction," J. Biol. Chem., 267:13361-13368 (1992).
Barney et al., "A Convenient Synthesis of Hindered Amines and .alpha.-Trifluoromethylamines from Ketones," Tetrahedron Letters, 31:5547-5550 (1990).
Batra and Alenfall, "Effects of Diverse Categories of Drugs on Human Colon Tumour Cell Proliferation," Anticancer Research 11:1221-1224 (1991).
Becalski et al., "Catalytic asymmetric hydrogenation of imines. Use of rhodium(I)/phosphine comploexes and characterization of rhodium(I)/imine complexes," Chemical Abstracts 116:558 at Abstract No. 14742U (1992).
Bertz et al., "Asymmetric Induction with Amidocuprates," J. Org. Chem. 51:4953-4959 (1986).
Bringmann et al., "Enantiomerically Pure-N-Boc Protected .beta.-Keto-.gamma.-Amino Acid Esters from Simple Keto Precursors: A Novel, Stereocontrolled Approach to Statine Derivatives with Any Desired Configuration," Synlett pp. 253-255 (May 1990).
Bringmann et al., "The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones," Liebigs Ann. Chem. pp. 795-805 (1990).
Brinster et al., "Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs," Proc. Natl. Acad. Sci. USA, 82:4438-4442 (1985).
Brown, "Extracellular Ca.sup.2+ Sensing, Regulation of Parathyroid Cell Function and Role of Ca.sup.2+ and Other Ions as Extracellular (First) Messengers," Physiological Reviews 71:371-411 (1991).
Brown et al, "Cloning and characterization of an extracellular Ca.sup.2+ sensing receptor from bovine parathryoid," Nature 366:575-580 (1993).
Brown et al., "A Comparison of the Effects of Divalent and Trivalent Cations on Parathyroid Hormone Release, 3',5'-Cyclic-Adenosine Monophosphate Accumulation, and the Levels of Inositol Phosphates in Bovine Parathyroid Cells," Endocrinology 127:1064-1071 (1990).
Brown et al., "High Extracellular Ca.sup.2+ and Mg.sup.2+ Stimulate Accumulation of Inositol Phosphates in Bovine Parathyroid Cells," FEBS Letters 218:113-118 (1987).
Brown et al., "Neomycin Mimics the Effects of High Extracellular Calcium Concentrations on Parathyroid Function in Dispersed Bovine Parathyroid Cells," Endocrinology, 128:3047-3054 (1991).
Brown et al., "Polyarginine, Polylysine, and Protamine Mimic the Effects of High Extracellular Calcium Concentrations on Dispersed Bovine Parathyroid Cells," J. Bone and Mineral Res., 6:1217-1225 (1991).
Buck and Axel, "A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition," Cell, 65:175-187 (1991).
Capecchi, "Altering the Gonome by Homologous Recombination," Science, 244:1288-1292 (1989).
Capuano et al., "Characterization of the Human Calcium Receptor Gene," J. Bone and Mineral Research 9(1):S145 at 98 (1994).
Chemical Abstracts Formula Index, vol. 110 p. 537F (1989).
Chemical Abstracts Formula Index, vol. 110 p. 1793F (1989).
Chen et al., "Divalent Cations Suppress 3,5'-Adenosine Monophosphate Accumulation by Stimulating a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein in Cultured Bovine Parathyroid Cells," Endocrinology 124:233-239 (1989).
Chen et al., "Effects of Fluoride on Parathyroid Hormone Secretion and Intracellular Second Messengers in Bovine Parathyroid Cells," Journal of Bone and Mineral Research 3:279-288 (1988).
Chen et al., "Injection of Bovine Parathyroid Poly(A).sup.+ RNA into Xenopus Oocytes Confers Sensitivity to High Extracellular Calcium," J. Bone Min. Res. 9:293-300 (1994).
Chen and Brown, "Diltiazem Analog TA-3090 Mimics the Actions of High Extracellular Ca.sup.2+ on Parathyroid Function in Dispersed Bovine Parathyroid Cells," J. Bone and Mineral Res. 5:581-587 (1990).
Clifton et al., "Arylethanolamines derived from salicylamide with alpha-and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers and related salicylamides," J. Med. Chem. 25:670-679 (1982).
Cooper et al., "Receptors," The Biochemical Basis of Neuropharmacology, 4th Edition, eds. J.R. Cooper, F.E. Bloom, R.H. Roth (New York:Oxford University Press, 1982) pp. 61-76.
Danks, "Reaction of Hydride Transfer Reducing Agents with (1-heterodiene) tricarbonyliron(0) Complexes and the Synthesis of Saturated Amines and Alcohols," Tetrahedron Lett. 35:4177-4178 (1994).
Davies and Ichihara, "Asymmetric Synthesis of R-.beta.-Amino Butanoic Acid and S-.beta.-Tyrosine: Homochiral Lithium Amide Equivalents for Michael Additions to .alpha.,.beta.-Unsaturated Esters," Tetrahedron: Asymmetry 2:183-186 (1991).
De Feo et al., "Natriuretic Peptide Receptors Regulate Endothelin Synthesis and Release From Parathyroid Cells," Proc. Natl. Acad. Sci. USA 88:6496-6500 (1991).
Dottavio-Martin and Ravel, "Radiolabeling of Proteins by Reductive Analytical Biochem., 87:562-565 (1978).
Duelfer et al., "Synthesis of 14C-dilevalol," J. Labelled Compld. Radiopharm 25:855-863 (1988).
Ferguson and Williams, "Cell-Surface Anchoring of Proteins Via Glycosylphosphatidylinositol Structures," Ann. Rev. Biochem., 57:285-320 (1988).
Fox et al., "A First Generation Calcimimetic Compound (NPS R-568) That Acts on the Parathyroid Cell Calcium Receptor: A Novel Therapeutic Approach for Hyperparathyroidism," J. Bone and Mineral Research 8(1):S181 at 260 (1993).
Fox et al., "NPS R-568 Inhibits Parathyroid Hormone Secretion and Stimulates Calcitonin Secretion in Hyperparathyroid Rats with Chronic Renal Failure," J. American Society of Nephrology 4:719 at 69P (1993).
Fox et al., "R-568 Acts on Calcium Receptors to Inhibit Parathyroid Hormone and Stimulate Calcitonin Secretion: A Novel Therapeutic Approach for Hyperparathyroidisum," J. American Society of Nephrology 4:719 at 120P (1993).
Fox et al., "Parathyroid Gland Calcium Receptor Gene Expression is Unaffected by Chronic Renal Failure or Low Dietary Calcium in Rats," J. Am. Soc. Nephrology 5:879 at 90P (1994).
Fox et al., "Physiologically Relevant PTH Levels are Anabolic on Bone in Ovariectomized Rats," Bone 16:194S at 434 (1995).
Fox et al., "Prevention of Hypocalcemia Prolongs the Plasma Parathyroid Hormone and Calcitonin Responses to the Calcimimetic Compound NPS R-568 in Rats," J. Bone Min. Res. 9(1):S409 at C396 (1994).
Fuji et al., "Endothelin as an Autocrine Factor in the Regulation of Parathyroid Cells," Proc. Natl. Acad. Sci. USA 88:4235-4239 (1991).
Fuleihan et al., "Effects of the Lectin Concanavalin-
Brown Edward M.
Garrett, Jr. James E.
Hebert Steven C.
NPS Pharmaceuticals Inc.
Sorensen Kenneth A.
The Brigham and Women's Hospital, Inc
Walsh Stephen
LandOfFree
Calcium receptor-active molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calcium receptor-active molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcium receptor-active molecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2200460