Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-10-03
1999-10-05
Ulm, John
Chemistry: molecular biology and microbiology
Vector, per se
435325, 435243, 4352523, 536 231, 536 234, 536 235, 536 2431, 530300, 530326, 530350, C12N 1563, C12N 1511, C12N 1512, C07K 700
Patent
active
059623144
ABSTRACT:
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
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Brown Edward M.
Garrett, Jr. James E.
Hebert Steven C.
Brigham and Women's Hospital
NPS Pharmaceuticals Inc.
Saoud Christine
Ulm John
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