Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
2000-02-29
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514614, 514607, 514646, 514649, A61K 3144, A61K 31135, A01N 3302, A01N 3718
Patent
active
060310030
ABSTRACT:
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
REFERENCES:
patent: 2276618 (1942-03-01), Kulz et al.
patent: 3202711 (1965-08-01), Fruhstorfer et al.
patent: 3262977 (1975-03-01), Harsanyi et al.
patent: 3536712 (1970-10-01), Keck et al.
patent: 3689524 (1972-09-01), Jack et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3862925 (1975-01-01), Sarantakis
patent: 3972859 (1976-08-01), Fujino et al.
patent: 4000197 (1976-12-01), Barfknecht et al.
patent: 4014937 (1977-03-01), Richardson
patent: 4098890 (1978-07-01), Molloy
patent: 4105602 (1978-08-01), Colescott et al.
patent: 4242355 (1980-12-01), Nedelec et al.
patent: 4289787 (1981-09-01), Molloy et al.
patent: 4360511 (1982-11-01), Baldwin et al.
patent: 4391826 (1983-07-01), Mills et al.
patent: 4487965 (1984-12-01), Himmele et al.
patent: 4587253 (1986-05-01), Halczenko et al.
patent: 4591605 (1986-05-01), Ray
patent: 4608391 (1986-08-01), Ginos et al.
patent: 4609494 (1986-09-01), Baldwin
patent: 4647446 (1987-03-01), Sargent et al.
patent: 4661635 (1987-04-01), Carson
patent: 4675321 (1987-06-01), Baldwin
patent: 4677101 (1987-06-01), Claremon et al.
patent: 4728660 (1988-03-01), Haynes et al.
patent: 4769483 (1988-09-01), Lombardi et al.
patent: 4797411 (1989-01-01), Crugnola et al.
patent: 4808718 (1989-02-01), Hartman et al.
patent: 4839369 (1989-06-01), Youssefyeh et al.
patent: 4916145 (1990-04-01), Tilley et al.
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4925873 (1990-05-01), Freidhoff
patent: 4945050 (1990-07-01), Sanford et al.
patent: 4967003 (1990-10-01), Rentzea et al.
patent: 4987071 (1991-01-01), Cech et al.
patent: 4988730 (1991-01-01), Korbonits et al.
patent: 4992378 (1991-02-01), Kelly et al.
patent: 5001251 (1991-03-01), MacManus et al.
patent: 5011834 (1991-04-01), Weber et al.
patent: 5021599 (1991-06-01), Beer et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5034514 (1991-07-01), Nitecki et al.
patent: 5045466 (1991-09-01), Morrison
patent: 5053337 (1991-10-01), Weinshank et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5082837 (1992-01-01), Palfreyman et al.
patent: 5334628 (1994-08-01), Maeda et al.
patent: 5504253 (1996-04-01), Van Wagenen et al.
patent: 5633404 (1997-05-01), Van Wagenen et al.
Anderson and Santi, "Phenylalanyl Transfer Ribonucleic Acid Synthetase from Escherichia coli B. Potent Inhibition by Analogues of N-Benzyl-2-phenylethylamine," J. Med. Chem. 19:1270-1275 (1976).
Arjona et al., "Sterochemistry of the reduction of the imino group. IV. Sterochemistry of the reduction of N-(1-phenylethyl)-1-alkyl-1-arylmethanimines," An. Quim. Ser. C 81(1):23-29 (1985).
Boyd et al., "Dynamic Sterochemistry of Imines and Derivatives. Part 18. Photosynthesis and Photoracemization of Optically Active Oxaziridines," J. Chem. Soc. Perkin Trans. I 4:849-855 (1985).
Fraser et al., "Substitution .alpha. to the Nitrogen in Dibenzylamine via Carbanion Intermediates," Can. J. Chem. 51:1109-1115 (1973).
Freifelder, "Selective Hydrogenolysis. Dehalogenation in the Presence of N-Benzyl Linkage," J. Org. Chem. 31(11):3875-3877 (1966).
Gracheva et al., "The Stereoselectivity of the Reactions of Schiff Bases with Organomagnesium Compounds," Zhural Organicheskoi Khimii 10(3):557-561 (1974).
Gracheva et al., "Stereodirection of Ketimine Reduction Reactions," Zhural Organicheskoi Khimii 9(6):1235-1239 (1973).
Grethe et al., "Syntheses in the Isoquinoline Series. Synthesis of 2,3-Dihydro-4(1H)-isoquinolones," J. Org. Chem. 33(2):491-494 (1968).
Hiroi et al., "A Highly Efficient and Recyclable Chiral Director for Asymmetric Synthesis of Sulfoxides," Chemistry Letters pp. 1595-1598 (1980).
Hiroi et al., "Studies on Chiral Organo-Sulfur Compounds. I. Asymmetric Synthesis of Sulfoxides with Optically Active o-Aminoalkylphenol Derivatives," Chem. Pharm. Bull. 31:3471-3485 (1983).
Hu et al., "Lithium hydride elimination in the reactions of organolithium compounds with imines: synthesis of secondary amines with branched groups," C.R. Acad. Sci. Paris Ser. C 284(4):195-198 (1977).
Hutton et al., "Organic Reagents for the Precipitation of Nitrate Ion. Part I. N-Substituted 1-naphthylmethylamines," J. Chem. Soc. (A) 11:1573-1579 (1966).
Ikegami and Yamada, "Chemistry of Sodium Borohydride and Diborane. II. Reduction of Schiff Bases with Diborane in Tetrahydrofuran," Chem. Pharm. Bull. 14(12):1389-1399 (1966).
Joshi and Mehrotra, "Reductive Coupling In Substituted Imines with Aluminium-Amalgam in Moist Ether," Nat. Acad. Sci. Letters (India) 3:268-272 (1980).
Kametani et al., "Studies on the Synthesis of Heterocyclic Compounds. Part 687. Asymmetric Synthesis of Salsolidine," J. Chem. Soc. Perkin Trans. 1 pp. 579-581 (1977).
Kang et al., "Rhodium(I)-catalysed Asymmetric Hydrogenation of Imines," J. Chem. Soc. Chem. Commun. pp. 1466-1467 (1988).
Katritzky et al., "Convenient Preparations of Imines and Symmetrical Secondary Amines Possessing Primary or Secondary Alkyl Groups," Synthesis 9:703-708 (1991).
Kienzle et al., "1,5-Dihydroimidazoquinazolinones as blood platelet aggregation inhibitors," Eur. J. Med. Chem.--Chem. Ther. 17:547-556 (1982).
Kozlov et al., "Reductive animation of 1-acetylcyclohexene by nitriles," Vestsi Akad. Navuk BSSR, Ser. Khim. Navuk pp. 55-58 (1977).
Langlois et al., "Asymmetric synthesis of amines by hydrosilylation of imines catalyzed by a chiral complex of rhodium," Tetrahedron Lett. 49:4865-4868 (1973).
Mori et al. "Formic Acid Reduction. XI. Reduction of Schiff Bases," Chem. Pharm. Bull. 19:1722-1727 (1971).
Neuvonen and Pihlaja, "Studies on the Benzoxazine Series. Part 3--Preparation and .sup.13 C NMR Structural Study of .gamma. Effects of Some N-Substituted 3,4-Dihydro-2H-1,3-benzoxazines," Magnetic Resonance in Chemistry 28:239-245 (1990).
Paulsen-Sorman et al., "Cytochrome P-455 nm Rai and Singh, Synthesis and reduction of Ketimines," Indian J. Chem. Sect. B 14B:377-378 (1976).
Polniaszek and Dillard, "Diastereoselective Addition of Organometallic Reagents to Chiral Immune Ions: Synthesis of (S)-(+)-Cryptostyline I," Tetrahedron Lett. 31:797-800 (1990).
Rai and Singh, "Synthesis and reduction of ketimines," Indian J. Chem. Sect. B 14B:377-378 (1976).
Schwartz and Hu, "Synthesis of Hindered Secondary Amines via Grignard Reagent Addition to Ketonitrones," Tetrahedron Lett. 13:1689-1692 (1992).
Strandridge et al., "Phenylalkylamines with Potential Psychotherapeutic Utility. 1. 2-Amino-1-(2,5-dimethoxy-4-methylphenyl) butane," J. Med. Chem. 19:1400-1404 (1976).
Standridge et al., "Phenylalkylamines with Potential Psychoterapeutic Utility. 2. Nuclear Substituted 2-Amino-1-phenylbutanes," J. Med. Chem. 23:154-162 (1980).
Van Dijk and Moed, "Synthesis of .beta.-Phenylethyloamine Derivatives X.sup.1* N-(Hydroxy- and Methoxy-Aralkyl) Derivatives," Recl. Trav. Chim. Pays-Bas 92:1281-1297 (1973).
Yamaguchi et al., "Asymmetric Reduction with Chiral Reagents from Lithium Aluminum Hydride and (S)-(-)-N-(o-Substituted benzyl)-.alpha.-phenylethylamines," J. Org. Chem. 42:1578-1581 (1977).
Kim et al., "Studies on the Structural Requirements for the Activity of the Skeletal Muscle Dihydropyridine Receptor/Slow Ca.sup.2+ Channel," J. Biol. Chem. 265:11858-11863 (1990).
Mikami et al., "Primary Structure and functional expression of the c
Balandrin Manuel F.
DelMar Eric G.
Moe Scott T.
Nemeth Edward F.
Van Wagenen Bradford C.
Borin Michael
NPS Pharmaceuticals Inc.
The Brigham and Women's Hospital
Tsang Cecilia J.
LandOfFree
Calcium receptor-active molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calcium receptor-active molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcium receptor-active molecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-683498