Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2005-09-06
2005-09-06
Shameem, Golam M M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S305000, C564S336000, C564S341000, C564S353000, C564S354000, C514S655000, C548S491000
Reexamination Certificate
active
06939895
ABSTRACT:
A novel calcium receptor active compound having the formula is provided:in-line-formulae description="In-line Formulae" end="lead"?Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2in-line-formulae description="In-line Formulae" end="tail"?wherein:Ar1is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino;X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino;R1, R2, R3, R4, R5, R6, R7, R8and R9are, for example, hydrogen or alkyl;Ar2is selected from the group consisting of aryl and heteroaryl;p is an integer of from 0 to 6, inclusive; and,q is an integer of from 0 to 14, inclusive.
REFERENCES:
patent: 2767168 (1956-10-01), Cheney
patent: 2770653 (1956-11-01), Hanslick et al.
patent: 2868833 (1959-01-01), Szabo et al.
patent: 2876236 (1959-03-01), Szabo et al.
patent: 5981599 (1999-11-01), Moe et al.
patent: 6362231 (2002-03-01), Sakai et al.
patent: 0 269 363 (1988-06-01), None
patent: 982 572 (1965-02-01), None
patent: 6-510531 (1994-11-01), None
patent: WO 94/18959 (1994-09-01), None
patent: 96/12697 (1996-05-01), None
Chemical Abstracts 122:55688 1995 Xueliang Huaxue Shiji 16 (3)132-135 1994.
Takeno et al., “A facile route to tetrahydroisoquinoline alkaloids via sulfoxide mediated cyclization.” Heterocycles, 35(1): 47-52, 1993.
Riley et al., “Synthesis and α-adrenolytic activity of chiral β-haloethylamines.” J.Pharm.Sci., 65(4):544-547, 1976.
Chemical Abstract, vol. 63, 1965, Columbus, Ohio, Abstract No. 2928b, Wellcome Foundation Ltd., “Improvements in and relating to quaternary ammonium compounds and the preparation thereof.” GB Patent Specification 982,572.
Chemical Abstract, vol. 60, 1964, Columbus, Ohio, Abstract No. 11246g, Robert P. Halliday et al., “Evaluation of certain hypotensive agents. V. substituted polymethylenediamines.” J. Pharm. Sci., 53(1):19-23, 1964.
Chemical Abstracts, vol. 60, 1964, Columbus, Ohio, Abstract No. 1692c, Jerry E. Robinson et al., “Hypotensives. VI. Disubstituted alkylenediamines and related compounds.” J.Med. Chemistry, 6(6): 805-807, 1963.
Chemical Abstracts, vol. 60, 1964, Columbus, Ohio, Abstract No. 4920f, L. Schusteritz et al., “Structure and action o piperazine and ethylenediamine derivatives.” Arzneimittel-Forsch., 9:628-633, 1959.
Chemical Abstracts, vol. 53, 1959, Columbus, Ohio, Abstract No. 12303e, Joseph L. Szabo et al., “Heterocyclic diamines and salts thereof.” US Patent No. 2, 876, 236.
Chemical Abstracts, vol. 53, 1959, Columbus, Ohio, Abstract No. 9251b, Joseph L. Szabo et al., “Aliphatic diamines and their salts.” US Patent No. 2, 868, 833.
Chemical Abstracts, vol. 53, 1959, Columbus, Ohio, Abstract No. 8788d, Roy S. Hauslick et al., “Diaralkylenediamine Preparation.” US Patent No. 2, 770, 653.
Chemical Abstracts, vol. 51, 1957, Columbus, Ohio, Abstract No. 7428i, Lee C. Cheney, “Purification of streptomycin.” US Patent No .2, 767, 168.
International Search Report, International Application No. PCT/JP97/02358.
Halliday et al. Evaluation of certain hypotensive agents V: Substituted polymethylenediamines. Journal of Pharmaceutical Sciences. 53: 19-23, 1964.
Robertson et al., Hypotensives. VI. Disubstituted alkylenediamines and related compounds. Journal of Medicinal Chemistry. 6:805-807, 1963.
Schusteritz et al., Struktur und wirkung von piperazin- und athylendiamin-derivaten. Arzneimittel Forschung, 9: 628-633, 1959.
Supplementary Partial European Search Report for Application No. EP 97 92 9555 mailed Aug. 12, 2004.
Nagao Rika
Sakai Teruyuki
Takami Atsuya
Foley & Lardner LLP
NPS Pharmaceuticals Inc.
Shameem Golam M M
LandOfFree
Calcium receptor-active compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calcium receptor-active compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcium receptor-active compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3446682