Calcium phosphate hydroxyapatite precursor and methods for makin

Compositions: coating or plastic – Coating or plastic compositions – Dental

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

106690, C09K 300

Patent

active

055452540

ABSTRACT:
Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.

REFERENCES:
patent: Re33161 (1990-02-01), Brown et al.
patent: Re33221 (1990-05-01), Brown et al.
patent: 3679360 (1972-07-01), Rubin
patent: 3787900 (1974-01-01), McGee
patent: 3913229 (1975-10-01), Driskell et al.
patent: 3929971 (1975-12-01), Roy
patent: 4097935 (1978-07-01), Jarcho
patent: 4497075 (1985-02-01), Niwa et al.
patent: 4599085 (1986-07-01), Riess et al.
patent: 4612053 (1986-09-01), Brown et al.
patent: 4880610 (1989-11-01), Constantz
patent: 4897250 (1990-02-01), Sumita
patent: 5034059 (1991-07-01), Constantz
patent: 5037639 (1991-08-01), Tung
patent: 5047031 (1991-09-01), Constantz
patent: 5053212 (1991-10-01), Constantz
patent: 5129905 (1992-07-01), Constantz
patent: 5238491 (1993-08-01), Sugihara et al.
patent: 5342441 (1994-08-01), Mandai et al.
Briner et al., "Significant of Enamel Remineralization", J. Dent. Res. 53-:239-243 (1974).
Silverstone, "Remineralization Phenomena", Caries Res. 11 (Supp. 1):59-84 (1977).
Brown, "Solubilities of Phosphates and Other Sparingly Soluble Compounds", Griffith et al., Environmental Phosphorous Handbook (John Wiley & Sons, New York 1973).
Miyazaki et al., "An Infrared Spectroscopic Study of Cement Formation of Polymeric Calcium Phosphate Cement," Jour of the Jap. Sco. for Dent Mats & Devices, vol. II, No. 2, 1992.
Brown et al., "Crystallography of Tetracalcium Phosphate," J. Res. Nat. Bur. Stands. 69A:547-551 (1965).
Brown and Chow, "Singular Points in the Chemistry of Teeth," JADR Abstract No. 120 J. Dent. Res. 54:74(1975).
Driskell et al., "Development of Ceramic and Ceramic Composite Devices for Maxillofacial Application", J. Biomed. Mat. Res. 6:345-361 (1972).
Gelhard et al., "Rehardening of Artificial Enamel Lesions in Vivo", Caries Res. 13:80-83 (1979).
Gregory et al., "Solubility of CaHPO.sub.4 2H.sub.2 O in the System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --H.sub.2 O at 5, 15, 25, and 37.5.degree. C.," J. Res. Nat. Bur. Stand. 74A:461-475 (1970).
Gregory et al., "Solubility of B--Ca.sub.3 (PO.sub.4).sub.2 in the System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --H.sub.2 O at 5, 15, 25 and 37.degree. C.," J. Res. Nat. Bur. Stand. 78A:667-674 (1974).
Hiatt et al., "Root Preparation I. Obduration of Dentinal Tubules in Treatment of Root Hypersensitivity", J. Periodontal. 43:373-380 (1972).
LeGeros et al., "Apatitic Calcium Phosphates: Possible Dental Restorative Materials" IADR Abstract No. 1482 (1982).
Levine, "Remineralization of Natural Carious Lesions of Enamel in Vitro," Brit. Dent. J., 137-:132-134 (1974). Guide to Dental Materials and Devices, 7th Ed. (ADA 1974), pp. 49-66.
McDowell et al., "Solubility of --Ca.sub.5 (PO.sub.4).sub.3 in the System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --H.sub.2 O at 5, 15, 25 and 37.degree. C.," J. Res. Nat. Bur. Stand. 81A:373-281 (1977).
McDowell et al., "Solubility Study of Calcium Hydrogen Phosphate Ion Pair Formation," Inorg. Chem. 10:1638-1643 (1971).
Moren et al., "Stability of Dicalcium Phosphate Dihydrate in Aqueous Solutions and Solubility of Octacalcium Phosphate," Soil Sci. Soc. Am. Proc. 21-99-102 (1960).
"NASA and Dentistry" (1977).
Patel et al., "Solubility of CaHPO.sub.4 2H.sub.2 O in the Quaternary System Ca(OH).sub.2 --H.sub.3 PO.sub.4 --NaCl--H.sub.2 O at 25.degree. C.," J. Res. Nat. Bur. Stands. 78A:675-681 (1974).
Pickel et al., "The Effect of a Chewing Gum Containing Dicalcium Phosphate on Salivary Calcium and Phosphate", Ala. J. Med. Sci. 2:286-287 (1965).
Zimmerman et al., "The Effect of Remineralization Fluids on Carious Lesions in Vitro", IADR Abstract No. 282 (1979).
Guide to Dental Materials and Devices, 7th Ed. (ADA 1974) p. 49.
Brown et al., (1988): A New Calcium Phosphate, Water Setting Cement, Cements Research Progress 1986, P. W. Brown, Ed., Westerville, Ohio: American Ceramic Society, pp. 352-379.
Chohayeb, A. A. et al., (1987): Evaluation of Calcium Phosphate as a Root Canal Sealer-Filler Material, J. Endod 13, 384-386.
Hong et al., (1989): The Periapical Tissue Reactions to a Calcium Phosphate Cement in the Teeth of Monkeys, J. Dent Res. (submitted).
Costantino et al. (1989): Evaluation of a New Hydroxyapatite Cement: Basic Chemistry and Histology, The Fifth Intl. Symposium on Facial Plastic Reconstructive Surgery of the Head and Neck, Toronto, Canada.
Friedman et al. (1989): Evaluation of a New Hydroxyapatite Cement: Obliteration and Reconstruction of the Cat Frontal Sinus, The Fifth Intl Symposium on Facial Plastic Reconstructive Surgery of the Head and Neck, Toronto, Canada.
Costantino et al. (1989): Evaluation of a New Hydroxyapatite Cement: Cranioplasty in a Cat Model, The Fifth Intl. Symposium on Facial Plastic Reconstructive Surgery of the Head and Neck, Toronto, Canada.
DeRijk, et al., (1986): Clinical Evaluation of a Hydroxyapatite Precipitate for the Treatment of Dentinal Hypersensitivity, Biomedical Engineering v. Recent Developments, Proc of 5th Southern Biomedical Engineering Conference, Subrata Saha, Ed., New York: Pergamon Press, pp. 336-339.
Grunninger et al. (1984): Evaluation of the Biocompatibility of a New Calcium Phosphate Setting Cement, J. Dent Res. 63 (Special Issue) Abst. No. 270.
Hanker et al., (1987): Calcium Phosphate Binders for Hydroxyapatite Particles for Bone Repair, J. Dent Res 66, Abst. No. 1144.
Lu et al. (1988): New Attachment Following the Use of a Novel Calcium Phosphate System, J. Dent Res 67: 352, Abst. No. 1913.
Schreiber et al. (1988): Remineralization of Root Caries Lesion by a Calcium Phosphate Slurry, J. Dent Res 67: Abst. No. 255.
Sugawara et al. (1987): A Calcium Phosphate Root Canal Sealer-Filler, J. Dent Res. 66: 296 Abst. No. 1516.
Sugawara et al (1988): Formation of Hydroxyapatite in Hydrogels from Tetracalcium Phosphate/Dicalcium Phosphate Mixtures, J. Dent Res (submitted).
Block et al. (1988): Correction of Vertical Orbital Dystopia with a Hydroxyapatite Orbital Floor Graft, J. Oral Maxillofac Surg 46: 420-425, 1988.
Salyer et al. (1989): Porous Hydroxyapatite as an Onlay Bone-Graft Substitute for Maxillofacial Surgery, Plas and Recon Surg 84, 2:236-244, 1989.
Kenney et al. (1988): The Use of a Porous Hydroxyapatite Implant in Periodontal Defects, J. Periodontal, :67-72 Feb. 1988.
Zide et al (1987): Hydroxyapatite Cranioplasty Directly Over Dura, J. Oral Maxillofac Surg 45:481-486, 1987.
Waite, et al. (1986): Zygomatic Augmentation with Hydroxyapatite, J. Oral Maxillofac Surg 44:349-352, 1986.
Verwoerd, et al. (1987): Porous Hydroxyapatite-perichondrium Graft in Cricoid Reconstruction, Acta Otolaryngol (Stockh) 1987; 103:496-502.
Grote, (1984): Tympanoplasty With Calcium Phosphate, Arch Otolaryngology 110:197-199, 1984.
Kent et al. (1983): Alveolar Ridge Augmentation Using Nonresorbable Hydroxyapatite With or Without Autogenous Cancellous Bone, J. Oral Maxillofac Surg 41:629-642, 1983.
Piecuch (1986): Augmentation of the Atrophic Endentulous Ridge with Porous Replamineform Hydroxyapatite (Interpore-200), Dental Clinics of North America 30, 2:291-305, 1986.
Misch (1987): Maxillary Sinus Augmentation for Endosteal Implants: Organized Alternative Treatment Plans, Int J Oral Implant 4, 2:49-58, 1987.
Chow, L. C., "Calcium Phosphate Materials: Reactor Response" Adv Dent Res 2(1): 191-184, Aug. 1988.
Fukase et al., "Setting Reactions and Compressive Strengths of Calcium Phosphate Cements", J Dent Res 69(12):1852-1856, Dec. 1990.
Chow, "Development of Self-Setting Calcium Ph

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Calcium phosphate hydroxyapatite precursor and methods for makin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Calcium phosphate hydroxyapatite precursor and methods for makin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcium phosphate hydroxyapatite precursor and methods for makin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1045509

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.