Calcium phosphate gel for adsorbing vaccines

Details Calcium phosphate gel for adsorbing vaccines Calcium phosphate gel for adsorbing vaccines

1975-12-11

1977-04-05

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 92, A61K 3900, A61K 3902, A61K 3912, A61K 4700

Patent

active

040162524

ABSTRACT:
An improved aqueous gel of calcium phosphate, useful for preparation of adsorbed vaccines, prepared by contacting an antigen with an aqueous gel obtained by reacting an aqueous solution of dibasic sodium phosphate with an aqueous solution of calcium chloride, wherein the calcium chloride solution is poured as rapidly as possible, within less than 3 minutes, into said phosphate solution, in a proportion substantially equal to 1 mol PO.sub.4 HNa.sub.2 for 1 mol CaCl.sub.2, under stirring; the mixture thus obtained is still stirred while its pH is adjusted to a value very near 7, and the gel formed is subsequently decanted and washed. The gel is composed of calcium and phosphate ions in proportions such that the ratio Ca/P is 1.62 to 1.85, and exhibits a settling rate of 1 to 20 mm in 10 minutes at 20.degree. C when containing 0.07 atoms Ca per liter.

REFERENCES:
patent: 2605229 (1952-07-01), Marcus
patent: 2967802 (1961-01-01), Towey et al.
patent: 3027229 (1962-03-01), Towey et al.
patent: 3608071 (1971-09-01), Relyveld
patent: 3925545 (1975-12-01), Relyveld

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