Compositions: coating or plastic – Coating or plastic compositions – Inorganic settable ingredient containing
Patent
1998-07-31
1999-10-19
Green, Anthony
Compositions: coating or plastic
Coating or plastic compositions
Inorganic settable ingredient containing
106 1505, 106 35, 106690, 423305, 423307, 424422, 424484, 424602, 424603, 4332281, 606 76, 623 16, C04B 1202, A61K 3306
Patent
active
059682531
ABSTRACT:
A flowable, paste-like composition capable of setting in a clinically relevant period of time into an antimicrobial agent loaded apatitic product having sufficient compressive strength to serve as a cancellous bone structural material is provided. The subject compositions are prepared by combining dry ingredients with a physiologically acceptable lubricant and an antimicrobial agent, where the dry ingredients comprise at least two different calcium phosphates. The subject compositions find use in a variety of different applications, including orthopaedic, dental and cranio-maxillofacial applications.
REFERENCES:
patent: 4108690 (1978-08-01), Heller
patent: 4587268 (1986-05-01), Pfirrmann
patent: 4684673 (1987-08-01), Adachi
patent: 4772468 (1988-09-01), Pfirrmann
patent: 4880610 (1989-11-01), Constanz
patent: 5037639 (1991-08-01), Tung
patent: 5047031 (1991-09-01), Constanz
patent: 5053212 (1991-10-01), Constanz et al.
patent: 5129905 (1992-07-01), Constanz
patent: 5151122 (1992-09-01), Atsumi et al.
patent: 5178845 (1993-01-01), Constanz et al.
patent: 5336264 (1994-08-01), Constanz et al.
patent: 5468489 (1995-11-01), Sakuma et al.
patent: 5496399 (1996-03-01), Ison et al.
patent: 5508342 (1996-04-01), Antonucci et al.
patent: 5569442 (1996-10-01), Fulmer et al.
patent: 5571493 (1996-11-01), Fulmer et al.
patent: 5580623 (1996-12-01), Fulmer et al.
patent: 5591453 (1997-01-01), Ducheyne et al.
patent: 5650176 (1997-07-01), Lee et al.
patent: 5676976 (1997-10-01), Lee et al.
patent: 5683461 (1997-11-01), Lee et al.
patent: 5683496 (1997-11-01), Ison et al.
patent: 5697981 (1997-12-01), Ison et al.
Bohner, Marc, et al., "Gentamicin-Loaded Hydraulic Calcium Phosphate Bone Cement As Antibiotic Delivery System," Journal Of Pharmaceutical Sciences (May 1997) vol. 86, No. (5):565-572.
Cimbollek, M., et al., "Antibiotics Impregnated Heart Valve Sewing Rings--Antibacterial Activity, Release Kinetics And Animal Pharmacokinetics," The 20.sup.th Annual Meeting of the Society For Biomaterials (Apr. 5-9, 1994) Boston, Massachusetts, USA, p. 490.
Constantz, Brent R., et al., "Skeletal Repair By In Situ Formation Of The Mineral Phase Of Bone," Science (Mar. 24, 1995) vol. 267:1796-1799.
Gerhart, T.N., et al., "Antibiotic-Loaded Biodegradable Bone Cement For Prophylaxis And Treatment Of Experimental Osteomyelitis In Rats," Journal Of Orthopaedic Research (1993) vol. 11:250-255. No Month.
Hamanishi, Chiaki, et al., "A Self-Setting TTCP-DCPD Apatite Cement For Release OF Vancomycin," Journal Of Biomedical Materials Research (Applied Biomaterials) (1996) vol. 33:139-143. No Month.
Nachiondo, J.M., et al., "Antibiotic Impregnation Of A Resorbable Calcium Phosphate Cement," The 20.sup.th Annual Meeting of the Society For Biomaterials (Apr. 5-9, 1994) Boston, Massachusetts, USA, p. 146.
Otsuka, Makoto, et al., "A Novel Skeletal Drug Delivery System Using Self-Setting Calcium Phosphate Cement. 2. Physicochemical Properties And Drug Release Rate Of The Cement-Containing Indomethacin," Journal Of Pharmaceutical Sciences (May 1994) vol. 83, No. (5):611-615.
Otsuka, Makoto, et al., "Drug Release From A Novel Self-Setting Bioactive Glass Bone Cement Containing Cephalexin And Its Physicochemical Properties*," Journal Of Biomedical Materials Research (1995) vol. 29:33-38. No Month.
Poser, Robert, et al., "Antibiotic Impregnation Of A Resorbable Calcium Phosphate Cement," ISFR-94, Sep. 27-Oct. 1, 1994, Kobe, Japan, p. 19.
Takechi, Masaaki, et al., "Effects Of Added Antibiotics On The Basic Properties Of Anti-Washout-Type Fast-Setting Calcium Phosphate Cement," Journal Of Biomed. Mater Res. (Feb. 1998) vol. 39:308-316.
Yu, Duncan, et al., "Self-Setting Hydroxyapatite Cement: A Novel Skeletal Drug-Delivery System For Antibiotics," Journal Of Pharmaceutical Sciences (Jun. 1992) vol. 81, No. (6):529-531.
Chemical Abstract No. 103:166174, abstract of Japanese Patent No. 60-103963, Jun. 1985.
Chemical Abstract No. 121:91861, abstract of Japanese Patent Specification No. 06-135840, May 1994.
Chemical Abstract No. 126:162142, abstract of an article by Trecant et al entitled "Dynamic Compaction: A new process to compact therapeutic agent-loaded calcium phosphates", Biomaterial, 18(2), 141-145, 1997 No Month.
Chemical Abstract No. 127:86015, abstract of an article by Radin et al entitled "Calcium phosphate ceramic coatings as carriers of vancomycin", Biomaterials, 18(11), 777-782, 1997 No Month.
Chemical Abstract No. 128:26952, abstract of PCT International Application No. 9741842, Nov. 1997.
European Patent Abstract No. EP000540819A1, abstract of European Patent Specification No. 540819, May 1993.
JAPIO Patent Abstract No. JP362019507A, abstract of Japanese Patent Specification No. 62-019507, Jan. 1987.
JAPIO Patent Abstract No. JP403267067A, abstract of Japanese Patent Specification No. 03-267067, Nov. 1991.
WPIDS Abstract No. 93-378243, abstract of German Patent Specification No. 4216496, Nov. 1993.
WPIDS Abstract No. 94-071797, abstract of Japanese Patent Specification No. 06-0249191, Feb. 1994.
Constantz Brent R.
Fulmer Mark
Poser Robert
Field Bret
Green Anthony
Norian Corporation
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