Compositions: ceramic – Ceramic compositions
Patent
1987-02-13
1989-08-29
Doll, John
Compositions: ceramic
Ceramic compositions
423305, 4332011, 623 16, A61F 124, C01B 2532, C04B 3500
Patent
active
048617334
ABSTRACT:
Calcium phosphates useful as bone substitute material or for the manufacture of prosthetic devices have been prepared from calcium hydroxyapatite material which has a uniformly permeable microporous structure characterized by a substantially uniform pore volume in the range from about 10 to about 90% and by a pronounced three-dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material of marine life by reacting said calcium hydroxyapatite material which has a calcium to phosphorus atomic ratio of about 1.66 with a phosphate-contributing or phosphorus-contributing moiety or with a calcium-contributing or calcium oxide-contributing moiety so as to alter the calcium to phosphorus Ca/P atomic ratio to yield a calcium phosphate material retaining the above-described microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material but having a calcium to phosphorus Ca/P atomic ratio less than or greater than 1.6, such as a calcium phosphate material comprising dicalcium phosphate and/or tricalcium phosphate and having a calcium to phosphorus Ca/P atomic ratio in the range 1.0-1.5 when the calcium hydroxyapatite material is reacted with said phosphate-contributing or phosphorus-contributing moiety or a calcium phosphate material having a calcium to phosphorus Ca/P atomic ratio greater than 1.66 up to 2.0 when the calcium hydroxyapatite material is reacted with said calcium-contributing or calcium oxide-contributing moiety and comprising tetracalcium phosphate.
REFERENCES:
patent: 3787900 (1974-01-01), McGee
patent: 3929971 (1975-12-01), Roy
patent: 4113500 (1978-09-01), Ebihara et al.
patent: 4230455 (1980-10-01), Hidaka et al.
patent: 4376168 (1983-03-01), Takani et al.
patent: 4654314 (1987-03-01), Takagi et al.
patent: 4693986 (1987-09-01), Vit et al.
patent: 4737411 (1988-04-01), Graves et al.
Doll John
Interpore International
Langel Wayne A.
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