Calcium-independent phospholipase A2 induces ischemic...

Details Calcium-independent phospholipase A2 induces ischemic... Calcium-independent phospholipase A2 induces ischemic...

2007-03-27

2007-03-27

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C435S198000, C536S023200

Reexamination Certificate

active

10737167

ABSTRACT:
A method for evaluating a compound to determine the relative or absolute therapeutic capability of a compound to pharmacologically inhibit ischemia induced activation of iPLA2β in an intact myocardium which comprises treating intact myocardium with a compound, inducing ischemia in the myocardium tissue and determining if there has been a change in expression of iPLA2β, its activity or in the iPLA2β regulating network and determining if there has been a change then that the compound is an anti-arrhythmia or myocardial salvage drug.

REFERENCES:
patent: 2005/0003388 (2005-01-01), Gross et al.
McHowat et al. Am. J Physiol. Jun. 1998, vol. 274, No. 6 Pt 1, pp. C1727-C1737.
Tang et al. [JBC 272 (13), Mar. 28, 1997, pp. 8567-75].

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