Calcium-independent phospholipase A.sub.2

Details Calcium-independent phospholipase A.sub.2 Calcium-independent phospholipase A.sub.2

1995-10-12

1998-06-30

Scheiner, Tom R.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

530350, C12N 920

Patent

active

057732760

ABSTRACT:
The present invention provides a substantially pure phopholipase A.sub.2 protein isolated and purified from rabbit kidney cortex, having a molecular weight of 28 kDa as determined by SDS-PAGE, is calcium independent, is cytosolic, has a specific activity of approximately 1.2 .mu.mol/mg protein/minute and a pH optimum of approximately 7.5 and exhibits a preferential hydrolysis toward sn-2 fatty acid from diradylglycerophospholipids. Also provided are various methods of using, inhibiting or measuring.

REFERENCES:
Portilla, J. Biol Chem (1996) 271(26) 15451-15457 (abstract).
Portilla, Am J. Physiol Renal Fluid Electrolyte Physiol 1992 262/3 31-3 (abstract).
Dai, J. Am. Soc. Nephrology 5(3) 1995 (abstract).
Portilla, Clin Res 39(2) 1991 (abstract).

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