Calcium-independent phospholipase A.sub.2

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

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435 71, 435 721, 435326, 435331, 5303871, 5303879, 5303881, 5303882, 53038826, 53038885, 5303891, 5303913, C12N 512, C07K 1640, A61K 39395, G01N 3353

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active

060048093

ABSTRACT:
The present invention provides a substantially pure phopholipase A.sub.2 protein isolated and purified from rabbit kidney cortex, having a molecular weight of 28 kDa as determined by SDS-PAGE, is calcium independent, is cytosolic, has a specific activity of approximately 1.2 .mu.mol/mg protein/minute and a pH optimum of approximately 7.5 and exhibits a preferential hydrolysis toward sn-2 fatty acid from diradylglycerophospholipids. Also provided are a first monoclonal antibody that specifically binds to the protein of claim 1 various methods of using, inhibiting or measuring said protein.

REFERENCES:
Dai an Portilla (J. Am. Soc. Nephrology 5(3):895 Presented Oct. 26-29, 1994).
Portilla and Dai, J. Biol. Chem 271 (26): 15451-1547, 1996.

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