Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1998-06-08
1999-12-21
Johnson, Nancy A
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435 71, 435 721, 435326, 435331, 5303871, 5303879, 5303881, 5303882, 53038826, 53038885, 5303891, 5303913, C12N 512, C07K 1640, A61K 39395, G01N 3353
Patent
active
060048093
ABSTRACT:
The present invention provides a substantially pure phopholipase A.sub.2 protein isolated and purified from rabbit kidney cortex, having a molecular weight of 28 kDa as determined by SDS-PAGE, is calcium independent, is cytosolic, has a specific activity of approximately 1.2 .mu.mol/mg protein/minute and a pH optimum of approximately 7.5 and exhibits a preferential hydrolysis toward sn-2 fatty acid from diradylglycerophospholipids. Also provided are a first monoclonal antibody that specifically binds to the protein of claim 1 various methods of using, inhibiting or measuring said protein.
REFERENCES:
Dai an Portilla (J. Am. Soc. Nephrology 5(3):895 Presented Oct. 26-29, 1994).
Portilla and Dai, J. Biol. Chem 271 (26): 15451-1547, 1996.
Portilla Didier
Shah Sudhir V.
Adler Benjamin Aaron
Johnson Nancy A
The Board of Trustees of the University of Arkansas
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