Calcium independent camp phosphodiesterase inhibitor antidepress

Details Calcium independent camp phosphodiesterase inhibitor antidepress Calcium independent camp phosphodiesterase inhibitor antidepress

1992-11-20

1994-03-15

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25537

Patent

active

052947300

ABSTRACT:
Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.

REFERENCES:
patent: 4857651 (1989-08-01), Brown et al.
patent: 4962223 (1990-10-01), Cannata et al.
Saccomano, et al., J. Med. Chem. (1991), 34, pp. 291-298.
Ring Systems Handbook (1988 Ed.), p. 304R/VI.

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