Calcium hydrogen phosphate, a method for preparing it, and an ex

Details Calcium hydrogen phosphate, a method for preparing it, and an ex Calcium hydrogen phosphate, a method for preparing it, and an ex

1994-07-08

1996-01-23

Langel, Wayne

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Phosphorus or phosphorus compound

423265, 423308, 423309, A61K 3342, C01B 2532

Patent

active

054863651

ABSTRACT:
The object of the present invention is to prepare a calcium hydrogen phosphate that has excellent binding properties, a large oil adsorption capacity and a specific surface area, and is therefore suitable as an excipient.
A scale-like calcium hydrogen phosphate is prepared by reacting phosphoric acid with an alkaline calcium compound such as quick lime, in the presence of a multivalent organic acid with coordinating ability, such as citric acid, to obtain a columnar calcium hydrogen phosphate, and then hydrothermally treating the obtained columnar calcium hydrogen phosphate at a temperature of 60.degree. C. or higher.

REFERENCES:
patent: 2697024 (1954-12-01), Moss et al.
patent: 4481175 (1984-11-01), Iino et al.
patent: 4721615 (1988-01-01), Griffith et al.
Kyowa Chemical Industry Co. Catalog entitled Ricamitt U-500 & Anhydrous Calcium Hydrogen Phosphate GS, published 1971.
Pharmacopoeia of Japan (12 Rev 1991) pp. D-1034 to D-1038.

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