Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1988-04-08
1990-02-20
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514877, 514871, 514904, 514905, A61K 31195
Patent
active
049027182
ABSTRACT:
This invention concerns novel calcium normalizing compositions containing as the active agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, and novel methods employing the compositions for normalizing or controlling calcium metabolism. The compounds include the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR1## and pharmaceutically acceptable N- (mono- and dicarboxylic acid) acyl derivatives and alkyl esters thereof, where in is an integer from 1 to 3.
REFERENCES:
patent: 2456820 (1949-01-01), Howe et al.
patent: 3773930 (1973-11-01), Mohammed et al.
patent: 4315028 (1982-02-01), Scheinberg
patent: 4409233 (1983-10-01), Tsukada et al.
patent: 4499076 (1985-02-01), Ohashi et al.
patent: 4649040 (1987-03-01), Ditha
patent: 4711780 (1987-12-01), Fahim
Chemical Abstracts 97:178781w (1982).
Donland's Medical Dictionary, p. 217 (1957).
Current Therapy, pp. 456-457 (1984).
Facts and Comparisons, pp. 54-55 (1983).
Physician's Desk Reference, 31st Ed. (1977), pp. 1127 and 1134.
Handbook of Non-Prescription Drugs, 8th Ed. (1987), p. 216-220.
Smolin et al., "The Use of Betaine for the Treatment of Homocystinurea" Journal Ped, Sep. 1981.
Johansson et al.; The Journal of Urology, "Biochemical and Clinical Effects of the Prophylactic Treatment of Renal Calcium Stones With Magnesium Hydroxide", 1980, pp. 770-774.
Preminger et al.; the Journal of Urology, "Prevention of Recurrent Calcium Stone Formation With Potassium Citrate Theraphy in Patients With Distal Renal Tubular Acidosis", vol. 134, pp. 20-23.
Pak et al.; the Journal of Urology, "Long-Term Treatment of Calcium Nephrolithiasis With Potassium Citrate", vol. 134, pp. 11-19.
Thornton; Current Veterinary Therapy IV, "Urinary Calculi In the Dog", 1971, pp. 695-706.
Cuperus et al.; Arthritis and Rheumatism, "Antiarthritic Drugs Containing Thoiol Groups Scavenge Hypochlorite and Inhibit Its Formation By Myeloperoxidase From Human Leukocytes", vol. 28, No. 11, November 1985, pp. 1228-1233.
Cho et al.; Journal of Parenteral and Enternal Nutrition, "D-Methionine Utilization in Young Miniature Pigs, Adult Rabbits, and Adult Dogs", vol. 4, No. 6, pp. 544-547.
Stegink et al.; Journal of Nutrition, "Plasma Methione Levels in Normal Adult Subjects after Oral Loading with 1-Methionine and N-Acetyl-1-Methionine", 1980, pp. 42-49.
Rotruck and Boggs; Journal of Nutrition, "Comparative Methionine", 1975, 105:pp. 331-337.
Tietz; Fundamentals of Clinical Chemistry, "Blood Gasses and Electrolytes", "Analysis of Calculi", 1976, pp. 901-903, pp. 1015-1025.
Bayless Robert K.
Hirsch Gerald P.
Kern Sandra S.
Friedman Stanley J.
Long J. F.
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