Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-10-31
1996-01-16
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31435
Patent
active
054847893
ABSTRACT:
A composition for storing tissue prior to transplantation is disclosed, wherein the tissue storage composition comprises a calcium channel blocker. Also disclosed is a method of storing tissue, comprising contacting the tissue to be stored with an amount of a calcium channel blocker sufficient to reduce tissue injury during storage under conditions such that viability of the tissue is maintained.
REFERENCES:
Chem Abst., 110:165854j (1989), Yang et al.
Chem. Abst., 110:107869g (1989), Zhang.
Weishaar et al., "The Beneficial Effect of a Calcium Channel Blocker, Diltiazem, on the Ischemic-Reperfused Heart", Journal of Molecular and Cellular Cardiology (1980), vol. 12, pp. 993-1009.
Belzer et al., "Principles of Solid-Organ Preservation by Cold Storage", Transplantation Overview, vol. 45, No. 4, Apr. 1988, pp. 673-676.
Currin et al., "Carolina Rinse Solution Protects Adenosine Triphosphate-Depleted Hepatocytes Against Lethal Cell Injury", Transplantation Proceedings, vol. 23, Feb. 1991, pp. 645-647.
Caldwell-Kenkel et al., "Selective Loss of Nonparenchymal Cell Vialbiity After Cold Ischemic Storage of Rat Livers", Transplantation, vol. 45, Apr. 1988, pp. 834-837.
Caldwell-Kenkel et al., "Reperfusion Injury to Endothelial Cells Following Cold Ischemic Storage of Rat Livers", Hepatology, vol. 10, (1989), pp. 292-299.
Peck, Robert C. and Lefer Allan M., "Protective effect of nifedipine in the hypoxic perfused cat liver", Agents and Actions, vol. 11, 4 (1981), pp. 421-424.
Thurman et al., "Protection of Liver by Calcium Entry Blockers", Annals of the New York Academy of Sciences, 522 (1988), pp. 757-770.
Lemasters John J.
Thurman Ronald G.
Fay Zohreh
The University of North Carolina at Chapel Hill
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