Calcium channel blockers

Details Calcium channel blockers Calcium channel blockers

2006-11-16

2010-02-23

Henley, III, Raymond J (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S255010, C514S315000, C514S381000, C514S391000, C544S106000, C544S381000, C544S391000

Reexamination Certificate

active

07666865

ABSTRACT:
Compounds of the formulawherein m is 0, 1 or 2;wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C;Y is H, OH, NH2, or an organic moiety of 1-20C, optionally additionally containing 1-8 heteroatoms selected from the group consisting of N, P, O, S and halo;each l1and l2is independently 0-5;l3is 0 or 1;each of R1, R2and R3is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R1and R2may independently be halo, COOR, CONR2, CF3, CN or NO2, wherein R is H or lower alkyl (1-4C) or alkyl (1-6C);n is 0 or 1;X is a linker;with the proviso that Y is not a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if l3is 0, and either l1and l2is 0 or 1 and if R1and/or R2represent F in the para position, Z cannot be C or N; andare useful to treat pain. Libraries of these compounds can also be used to identify antagonists for other targets.

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