Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-02-11
1994-05-17
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548494, C07D20920, A61K 31405
Patent
active
053129288
ABSTRACT:
A substantially pure compound of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, independently, is H, CH.sub.3, CF.sub.3, F, Cl, Br, I, OH, OCH.sub.3, OCF.sub.3, SH, SCH.sub.3, NH.sub.2, N.sub.3, NO.sub.2, CN, COOH, CONH.sub.2, CH.sub.2 CONH.sub.2, or SO.sub.2 NH.sub.2 ;
REFERENCES:
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4950739 (1990-08-01), Cherksey et al.
Jasys, V. J. et al., "Isolation, Structure Elucidation, and Synthesis of Novel Hydroxylamine-Containing Polyamines from the Venom of the Agelenopsis aperta Spider", J. Am. Chem. Soc., 112:6696-6704 (1990).
Skinner, W. S. et al., "Chemical Characterization of Acylpolyamine Toxins from Venom of a Trap-Door Spider and Two Tarantulas", Toxicon, 28:541-546 (1990).
Adams, M. E. et al., "Structures and Biological Acitivities of Three Synaptic Antagonists From Orb Weaver Spider Venom", Biochem. Biophys. Res. Comm., 148:678-683 (1987).
Skinner, W. S. et al., "Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis aperta", J. Biol. Chem, 264:2150-2155 (1988).
Llinas, R. et al., "Blocking and isolation of a Calcium Channel From Neurons in Mammals and Cephalopods Utilizing a Toxin Fraction (FTX) From Funnel-Web Spider Poison", Proc. Natl. Acad. Sci., USA, 86:1689-1693 (1989).
Adams, M. E. et al., "Two Classes of Channel-Specific Toxins From Funnel Web Spider Venom", J. Chem. Physiol A., 164:333-342 (1989).
Daly Deborah
Goldin Stanley M.
Hu Lain-Yen
Katragadda Subbarao
Knapp Andrew G.
Cambridge Neuroscience
Springer David B.
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