Calcium-binding protein

Details Calcium-binding protein Calcium-binding protein

1997-03-31

1999-02-16

Grimes, Eric

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 4353201, 435325, 536 235, 536 2431, C12N 1512, C12N 1563, C12P 2102, C12Q 168

Patent

active

058719709

ABSTRACT:
The present invention provides a human calcium-binding protein (HCBP) and polynucleotides which identify and encode HCBP. The invention also provides expression vectors and host cells, agonists, antibodies, and antagonists. In addition, the invention provides methods for producing HCBP and for treating or preventing disorders associated with the expression of HCBP.

REFERENCES:
Asakura, K., et al., "Clone Rem1, ORF, fragment," TRROD EMBL Database Entry Q63399, Accession No. Q63399, XP002070130, Nov. 1, 1996.
Hillier, L., et al., "Homo sapiens cDNA clone 376349 5' similar to PIR:JC4173 reticulocalbin homolog-human," EMEST EMBL Database Entry HSA41328, Accession No. AA041328, XP002070131, Sep. 1, 1996.
Hillier, L., et al., "Homo sapiens cDNA clone 664259 5' similar to TR:G780361," EMEST EMBL Database entry HS1150166, Accession No. AA232452, XP002070132, Mar. 6, 1997.
Hillier, L., et al., "Homo sapiens cDNA clone 811903 5' similar to SW:RCA1 mouse Q05186 reticulocalbin precursor," EMEST EMBL Database entry HS1246269, Accession No. AA456267, XP002070133, Jun. 7, 1997.
Hillier, L., et al., "Mus musculus cDNA clone 420903 5' similar to PIR:JC4173 reticulocalbin homolog-human," EMEST EMBL Database entry MMW02, Accession No. W91002, XP002070134, Jul. 9, 1996.
Marra, M., et al., "Mus musculus cDNA clone 386402 5' similar to GB:D13003 mus musculus reticulocalbin mRNA, complete CDs," EMEST EMBL Database entry MM38328, Accession No. W64383, XP002070135, Jun. 11, 1996.
Marra, M., et al., "Mus musculus cDNA clone 463711 5' similar to PIR:JC4173 reticulocalbin homolog-human," EMEST EMBL Database entry MMA28649, Accession No. AA028649, XP002070136, Aug. 17, 1996.
Ozawa, M. et al., "Reticulocalbin, a Novel Endoplasmic Reticulum Resident Ca.sup.2+ --binding Protein with Multiple EF-hand Motifs and a Carboxyl-terminal HDEL Sequence." J. Biol. Chem. (1993) 268(1):699-705.
Ozawa, M. "Cloning of a Human Homologue of Mouse Reticulocalbin Reveals Conservation of Structural Domains in the Novel Endoplasmic Reticulum Resident Ca.sup.2+ --Binding Protein with Multiple EF-Hand Motifs." J. Biochem. (1995) 117:1113-1119.

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