Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-01-10
1992-04-21
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514219, 514252, 514254, 514255, 514266, 514321, 514326, 514393, 514398, 514401, 514402, A61K 3155, A61K 31505, A61K 3150, A61K 31415
Patent
active
051068451
ABSTRACT:
The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH.sub.2).sub.n in which n is an integer from 2-10, ##STR2## A is a substituent selected from the group consisting of --NH--(CH.sub.2).sub.m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar.sub.1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, and trifluoromethyl; and R is represented by either hydrogen or a C.sub.1-4 alkyl; R.sub.1 is represented by hydrogen or a C.sub.1-4 alkyl; the optional isomers and tautomers thereof; and the pharmaceutically acceptable acid addition salts thereof, and their use as calcium antagonists.
REFERENCES:
patent: 3840554 (1974-10-01), Wittekind et al.
patent: 4234894 (1980-11-01), Rasmussen
patent: 4243667 (1981-01-01), Rasmussen
patent: 4829065 (1989-05-01), Pascal et al.
Goodman and Gillman's Pharmacological Basis of Therapeutics (MacMillan, N.Y., New York, 1985) pp. 820-822.
Carr Albert A.
Cheng Hsien C.
Kane John M.
Merrell Dow Pharmaceuticals Inc.
Shah Mukund J.
Ward E. C.
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