Calcium-activated chloride channel proteins and their use in...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S012200, C530S328000, C530S350000

Reexamination Certificate

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07338937

ABSTRACT:
Nucleotide sequences which encode a mammalian lung endothelial cell adhesion molecule are disclosed. Also disclosed are nucleotide sequences which encode a lung endothelial cell adhesion molecule-associated protein. Recombinant lung endo-thelial cell adhesion molecule or recombinant lung endothelial cell adhesion molecule-associated protein may be obtained by culturing in a medium a host cell genetically engineered to contain and express a nucleotide sequence according to the present invention, and recovering the recombinant lung endothelial cell adhesion molecule-associated protein or recombinant lung endothelial cell adhesion molecule-associated protein from the culture medium.

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Gruber, Achim D., Kevin D. Schreur, Hong-Long Ji, Catherine M. Fuller, and Bendicht U. Pauli, “Molecular Cloning And Transmembrane Structure Of hCLCA2 From Human Lung, Trachea, And Mammary Gland,”Am. J. Physiol.,1999, pp. C1261-C1270, vol. 276.
Kerem, Bat-Sheva, Johanna M. Rommens, Janet A. Buchanan, Danuta Markiewicz, Tara K. Cox, Aravinda Chakravarti, Manuel Buchwald, and Lap-Chee Tsui, “Identification Of The Cystic Fibrosis Gene: Genetic Analysis,”Science,Sep. 8, 1989, pp. 1073-1080, vol. 245.
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