Calcitonin salmon analogues

Details Calcitonin salmon analogues Calcitonin salmon analogues

1997-08-08

2000-08-22

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530307, 530345, 436 86, A61K 3823, C07K 100

Patent

active

06107277&

ABSTRACT:
Salcatonin (i.e. salmon calcitonin) analogues of formula R1-Ser-Asn-Leu-Ser-Thr-Cys(SR2)-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Ly s-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (I) are disclosed, in which R1=-Cys-S--H, -Cys--OH, -Cys-S-ether or -Cys-S-ester (where the ether or ester residue has 2-5C) or a corresponding salt or isomer; R2=H, OH, ester or ether residue of 2-5C or acetamidomethyl, or a corresponding salt or isomer.

REFERENCES:
patent: 3926938 (1975-12-01), Hughes et al.
Abstract JP 1230530.
Abstract J03052821.
Abstract EP 156772.
Abstract JP 63316737.
Database Toxlit on STN, No. 1972:33662 Toxit; Barlet JP, `Effects of Procin, Salmon, and human calcitonin on urinary excretion of some eclectrolytes in sheep`, J. Endocrinology (abstract), 1972.
Database EMBASE on STN, No. 74005418 Embase; Garijo et al. `Effects of treatment with caliconin in case of myeloma lgG with hypercalcima and hyperuricemia`, Rev. Clin. Esp. (abstract), 1973.
Database MARPAT on STN, No. 124:30425 Marpat; Datsumata et al., JP 07188297, Jul. 25, 1995.

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