Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Calcitonin; related peptides
Patent
1987-12-04
1991-09-17
Brown, Johnnie R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Calcitonin; related peptides
530317, 530324, C07K 736
Patent
active
050496549
ABSTRACT:
A compound of the formula ##STR1## wherein Y is sulfur or methylene and A is Asn or Asp, or a pharmaceutically acceptable salt thereof is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cranial circulation.
REFERENCES:
patent: 4743677 (1988-05-01), Noda et al.
Sako et al., Chem. Ab., 1987, 107(34), ab #7563x, Pept. Chem., 1986 pub.
"Isolation and Characterization of Human Calcitonin Gene-Related Peptide", Nature, vol. 308, No. 19, Apr. 1984, by H. Morris, et al., pp. 746-748.
"Calcitonin Gene-Related Peptide is a Potent Vasodilator", Nature, vol. 313, No. 3, Jan. 1985, by S. Brain et al., pp. 54-56.
"The Myotropic and Plasma-Calcium Modulating Effects of Calcitonin Gene-Related Peptide (CGRP)", Neuropeptides, vol. 4, 1984, by J. Tippins et al., pp. 425-434.
"Studies on Peptides, CXLII, 1.2) Synthesis of Des-1-Ala-des-.alpha.-amino-Human Calcitonin Gene-Related Peptide", Chem. Pharm. Bull., vol. 34, No. 9, Sep. 1986, by A. Otaka et al., pp. 3915-3918.
"Isolation and Partial Characterization of the Calcitonin Gene in a Lower Vertebrate", Febs Letters, vol. 203, No. 1, Jul. 1986, by S. Minvielle et al., pp. 7-10.
Hori Masayuki
Morita Kaoru
Noda Toshiharu
Uzawa Toyonobu
Brown Johnnie R.
Maebius Stephen B.
Toyo Jozo Kabushiki Kaisha
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