Calcitonin-gene-related peptide derivatives

Details Calcitonin-gene-related peptide derivatives Calcitonin-gene-related peptide derivatives

1988-07-21

1991-02-12

Lee, Mary C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

C07K 500, A61K 3702

Patent

active

049925300

ABSTRACT:
A compound of the formula ##STR1## wherein R is H or H-Ala-NH- and when A is Asp, B is Asp or Glu, C is Leu and D is Val; when A is Asn and B is Gly, C is Phe and D is Gly; when A is Asn, B is Asp or Glu and C is Leu, D is Gly; and when A is Asn, B is Asp or Glu, and C is Phe, D is Val, or a pharmaceutically acceptable salt thereof, is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cerebral circulation.

REFERENCES:
patent: 4743677 (1988-05-01), Noda et al.
"Isolation and Partial Characterization of the Calcitonin Gene in a Lower Vertebrate", FEBS, vol. 203, No. 1, Jul. 1986, by S. Minvielle et al., pp. 7-10.
"Isolation and Characterization of Human Celcitonin Gene-Related Peptide", Nature, vol. 308, No. 19, Apr. 1984, by H. Morris et al., pp. 746-748.
"A Second Human Calcitonin/CGRP Gene", Federation of European Biochemical Societies, vol. 183, No. 2, Apr. 1985, by P. Steenbergh et al., pp. 403-407.
"The Myotropic and Plasma-Calcium Modulating Effects of Calcitonin Gene-Related Peptide", Neuropeptides, vol. 4, Part 5, 1984, by J. Tippins et al., pp. 425-434.
"Calcitonin Gene-Related Peptide is a Potent Vasodilator", Nature, vol. 313, No. 3, Jan. 1985, by S. Brain et al., pp. 54-56.

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