Calcitonin derivatives

Details Calcitonin derivatives Calcitonin derivatives

1997-09-22

1999-11-02

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530317, 930 60, A61K 3800

Patent

active

059772980

ABSTRACT:
The present invention relates to compounds represented by formula (I): ##STR1## wherein Z represents Gly or Cys; X represents an (.alpha.-amino acid residue; Y represents a natural calcitonin moiety, a partial natural calcitonin peptide moiety, or a natural calcitonin-like peptide moiety; m represents an integer of 5-8, .alpha.-amino acid residues represented by X being the same or different; and n represents an integer of 0-3; provided that when m is 5, the sequence of 4 C-terminal residues of --(X).sub.m -- is different from the sequence of the third to sixth amino acids of natural calcitonin, and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 5552520 (1996-09-01), Kim
patent: 5639860 (1997-06-01), Tanaka
Katahira et al., Bioorganic & Medical Chemistry 3(9):1273-80, 1995.
Morishita et al., The Journal of Antibiotics 47(3):269-275, Mar. 1994.
Yamasaki et al., The Journal of Antibiotics 47(3):276-80, Mar. 1994.
Karaki et al., European Journal of Pharmacology 262:255-59, Sep. 1994.

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