Calcitonin-containing emulsion for nasal administration

Details Calcitonin-containing emulsion for nasal administration Calcitonin-containing emulsion for nasal administration

1991-07-23

1994-01-25

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 514808, A61K 3324, A61K 906, A61K 3730, C07K 736

Patent

active

052815803

ABSTRACT:
The present invention is to provide emulsion preparations for nasal administration containing calcitonins, which are safely and effectively administrated compared with the conventional calcitonin preparations. The emulsions are prepared by using a calcitonin as the active ingredient, an azacycloalkane derivative as the absorption promotor such as 1-[2-(decylthio)ethyl] azacyclopentan-2-one, and glycyrrhizic acid or its salt.

REFERENCES:
patent: 4690852 (1987-09-01), Katagani et al.
patent: 4835132 (1989-05-01), Suzuki et al.
patent: 4882359 (1989-11-01), Nakagawa et al.
patent: 5026825 (1991-06-01), Grebow et al.
Chemical Abstracts, vol. 110, No. 16, Apr. 17, 1989, Columbus Ohio, USA N. Yamamoto et al. "Intranasal compositions containing calcitonins or parathyroid hormones" p. 414 589a & Jpn. Kokai Tokkyo Koho JP 63,243,033 (88,243,033).
Patent Abstracts of Japan, unexamined applications, section C, vol. 12, No. 110, Apr. 8, 1988 The Patent Office Japanese Government p. 159 C 486 *Kokai-no. 62-238 261 (Hisamitsu Pharmaceut Co Inc.)*.
Chemical Abstracts, vol. 105, No. 18, Nov. 3, 1986, Columbus, Ohio, USA T. Hasumi et al. "Nasal formulations containing calcitonin and amino acids" p. 375, col. 2, abstract no. 158 833v & Jpn. Kokai Tokyo Koho JP 61,118,325 (86,118,325).
Chemical Abstracts, vol. 109, No. 22, Nov. 28, 1988, Columbus, Ohio, USA T. Hasumi et al. "Nasal compositions containing calcitonin" p. 456, col. 2, abstract-no. 197 195r & Jpn. Kokai Tokkyo Koho JP 63 10, 735 (88 10,735).
Japanese Publication 3-83925.
Japanese Publication 3-83926.
Delivery System for Peptide Drugs, Plenum Press, 233-242, 1986.

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