Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1995-06-01
2000-12-12
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
536 241, C12N 1563, C07H 2104
Patent
active
06159735&
ABSTRACT:
A DNA element which was isolated from the upstream regulatory region of the CT/CGRP gene and which exhibits cell-specific enhancement of transcription is described. The enhancer activity of the element is further regulated by members of the superfamily of steroids and retinoids which increase or decrease transcription in a cell-specific manner. Methods of gene regulation and therapeutic uses involving the DNA element are also described. Furthermore, proteins which bind to the element and regulate transcription of genes under the control of the DNA element are also described. These proteins can be used for purposes of regulation of gene expression.
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Lanigan Thomas M.
Russo Andrew F.
Tverberg Lois A.
Hanley, Esq. Elizabeth A.
Lauro, Esq. Peter C.
Schwartzman Robert A.
University of Iowa Research Foundation
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