Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-01
1999-11-02
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
514 44, 4351723, C12Q 168
Patent
active
059767880
ABSTRACT:
A DNA element which was isolated from the upstream regulatory region of the CT/CGRP gene and which exhibits cell-specific enhancement of transcription is described. The enhancer activity of the element is further regulated by members of the superfamily of steroids and retinoids which increase or decrease transcription in a cell-specific manner. Methods of gene regulation and therapeutic uses involving the DNA element are also described. Furthermore, proteins which bind to the element and regulate transcription of genes under the control of the DNA element are also described. These proteins can be used for purposes of regulation of gene expression.
REFERENCES:
patent: 4720483 (1988-01-01), Jansz et al.
Ausubel, F.M. et al., (Eds.), Short Protocols in Molecular Biology, 2nd ed., unit. 1.7-1.8, (John Wiley & Sons)., NY 1992, pp. 1-20 to 1-27.
Besnard, P., et al., (1989) "Additive effects of dexamethasone and calcium on the calcitonin mRNA level in adrenalectomized rats", FEBS Letters, vol. 258, No. 2, pp. 293-296.
Burns, D.M., et al., (1989) "A Neuroendocrine Peptide Derived from the Amino-Terminal Half of Rat Procalcitonin", Molecular Endocrinology, vol. 3, No. 1, pp. 140-147.
Copp, D.H., (1992) "Remembrance: Calcitonin: Discovery and Early Development", Endocrinology, vol. 131, No. 3, pp. 1007-1008.
Cote, G.J., and Gagel, R.F., (1986) "Dexamethasone Differentially Affects the Levels of Calcitonin and Calcitonin Gene-related Peptide mRNAs Expressed in a Human Medullary Thyroid Carcinoma Cell Line", J. Biol. Chem., vol. 261, No. 33, pp. 15524-15528.
Denis-Donini, S., (1989) "Expression of dopaminergic phenotypes in the mouse olfactory bulb induced by the calcitonin gene-related peptide", Nature, vol. 339, pp. 701-704.
Diamond, M.I., et al., (1990) "Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element", Science, vol. 249, pp. 1266-1277.
Fontaine, B., et al., (1986) "Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes" Neurosci. Lett, vol. 71, No. 1, pp. 59-65.
Giguere, V., et al., (1987) "Identification of a receptor for the morphogen retinoic acid", Nature, vol. 330, pp. 624-629.
Glass, C.K., et al., (1990) "Multiple Cell Type-Specific Proteins Differentially Regulate Target Sequence Recognition by the .alpha. Retinoic Acid Receptor", Cell, vol. 63, pp. 729-738.
Glass, C. K., et al., (1989) "Positive and Negative Regulation of Gene Transcription by a Retinoic Acid-Thyroid Hormone Receptor Heterodimer", Cell, vol. 59, pp. 697-708.
Hu, Y-F., et al., (1990) "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity", Genes & Development, vol. 4, pp. 1741-1752.
Johnson , J.E., et al., (1990) "Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors", Nature, vol. 346, pp. 858-861.
Kristie, T.M., et al., (1989) "The octamer-binding proteins from multi-protein-DNA complexes with the HSV .alpha.TIF regulatory protein", The EMBO Journal, vol. 8, No. 13, pp. 4229-4238.
Leff, S.E., et al., (1986) "Complex Transcriptional Units: Diversity in Gene Expression by Alternative RNA Processing", Annu. Rev. Biochem, vol. 55, pp. 1091-1117.
Mangelsdorf, D.J., et al., (1990) "Nuclear receptor that identifies a novel retinoic acid response pathway", Nature, vol. 345, pp. 224-229.
Manz, B., et al., (1983) "Methyl 17.beta.-Carboxyester Derivatives of Natural and Synthetic Glucocorticoids: Correlation Between Receptor Binding and Inhibition of in vitro Phytohaemagglutinin-Induced Lymphocyte Blastogenesis", J. Clin. Chem. Clin. Biochem., vol. 21, pp. 69-75.
Mermod, N., et al., (1988) "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro", Nature, vol. 332, pp. 557-561.
Mordacq, J.C. and Linzer, D.I.H., (1989) "Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression", Genes & Development, vol. 3, pp. 760-769.
Muszynski, M., et al., (1983) "Glucocorticoids stimulate the production of preprocalcitonin-derived secretory peptides by a rat medullary thyroid carcinoma cell line", J. Biol. Chem., vol. 258, No. 19, pp. 11678-11683.
Naveh-Many, T. and Silver, J., (1988) "Regulation of Calcitonin Gene Transcription by Vitamin D Metabolites In Vivo in the Rat", J. Clin. Invest., vol. 81, pp. 270-275.
Nelson, C., et al., (1988) "Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor", Science, vol. 239, pp. 1400-1405.
Nelson, C., et al., (1990) "Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs", Genes & Development, vol. 4, pp. 1035-1043.
New, H.V., and Mudge, A.W., (1986) "Calcitonin gene-related peptide regulates muscle acethylcholine receptor synthesis" Nature, vol. 323, pp. 809-811.
Petkovich, M., et al., (1987) "A human retinoic acid receptor which belongs to the family of nuclear receptors", Nature, vol. 330, pp. 444-450.
Pressley, L. and Funder, J.W., (1975) "Glucocorticoid and Mineralocorticoid Receptor in Gut Mucosa", Endocrinology, vol. 97, pp. 588-596.
Ray, A., et al., (1990) "On the Mechanism for Efficient Repression of the Interleukin-6 Promoter by Glucocorticoids: Enhancer, TATA Box, and RNA Start Site (Intr Motif) Occlusion", Mol. Cell Biolog., vol. 10, No. 11, pp. 5736-5741.
Rosenfeld, M.G., et al., (1984) "Alternative RNA Processing: Determining Neuronal Phenotype", Science, vol. 225, pp. 1315-1320.
Rosenfeld, M.G., et al., (1983) "Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing", Nature, vol. 304, pp. 129-135.
Russo, A.F., et al., (1988) "Differential Regulation of the Coexpressed Calcitonin/.alpha.-CGRP and .beta.-CGRP Neuroendocrine Genes", J. Biol. Chem., vol. 263, No. 1, pp. 5-8.
Russo, A.F., et al., (1992) "Neuronal Properties of a Thyroid C-Cell Line: Partial Repression BY Dexathosone and Retinoic Acid", Mol. Endocrinol., vol. 6, pp. 207-218.
Scholer, H.R., (1991) "Octamania: The POU factors in murine development", Trends in Genet., vol. 7, No. 10, pp. 323-329.
Stolarsky-Fredman, L.,et al., (1990) "A Tissue- Specific Enhancer in the Rat- Calcitonin GRP Gene is Active in Both Neural and Endocrine Cell Types," Molecular Endocrinology, vol. 4(3), pp. 497-504.
Tverberg, L.A. and Russo, A.F., (1992) "Cell-specific Glucocorticoid Repression of Calcitonin/Calcitonin Gene-related Peptide Transcription", J. Biol. Chem., vol. 267, No. 25, pp. 17567-17573.
Tverberg, L.A. and Russo, A.F., (1993) "Regulation of the Calcitonin/Calcitonin Gene-related Peptide Gene by Cell-specific Synergy between Helix-Loop-Helix and Octamer-binding Transcription Factors", J. Biol. Chem., vol. 268, No. 21, pp. 15695-15693.
Yang, N., et al., (1991) "Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor", Proceedings of the National Academy of Science, vol. 87, pp. 3559-3563.
Zeytin, F.N., et al., (1987) "Calcium, Dexamethasone, and the Antiglucocorticoid RU-486 Differentially Regulate Neuropeptide Synthesis in a Rat C Cell Line", Endocrinology, vol. 121, No. 1, pp. 361-370.
Ball et al, Nuc. Acids. Res., 20(1), 1992, pp. 117-123.
Wet et al, Mol. and Cellular Biology, 7(2), 1987 pp. 725-737.
Maniatis et al, Molecular Cloning, 1989, Cold Spring Habor Press.
Russo Andrew F.
Tverberg Lois A.
Chambers Jasemine C.
Chinn Linda M.
Clark Deborah J. R.
Hanley Elizabeth A.
University of Iowa Research Foundation
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