Calcitonin analogs with C-terminal D-amino acid substituents

Details Calcitonin analogs with C-terminal D-amino acid substituents Calcitonin analogs with C-terminal D-amino acid substituents

1985-08-16

1987-03-24

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

514808, C07K 736, A61K 3724

Patent

active

046526277

ABSTRACT:
New calcitonin analogs are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid substituent in at least one of the positions 31 and 32 instead of the natural L-amino acid units. The calcitonin analog may be analogs of salmon, eel, chicken, bovine, porcine, ovine, murine or human calcitonins.

REFERENCES:
patent: 4414149 (1983-11-01), Orlowski et al.
patent: 4469632 (1984-09-01), Orlowski et al.
Lasmoles et al., FEBS, vol. 180, No. 1, 113-116 (1985).

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