Calcineurin inhibitory compounds and anchoring protein to induce

Details Calcineurin inhibitory compounds and anchoring protein to induce Calcineurin inhibitory compounds and anchoring protein to induce

1995-03-15

1998-04-28

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435355, 435372, 4353723, 435375, 435724, 514 2, 514 13, 514 15, 424 851, 424 852, 4241851, 4241981, 4242781, 4242831, 4241931, A61K 3800, C12N 508

Patent

active

057443548

ABSTRACT:
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells.

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