Calcification-resistant synthetic biomaterials

Details Calcification-resistant synthetic biomaterials Calcification-resistant synthetic biomaterials

1994-01-21

1995-07-25

Welsh, Maurice J.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

At least one aryl ring which is part of a fused or bridged...

525453, 528 59, 528 72, 528 73, 536 21, 514 56, C08G 1810

Patent

active

054362911

ABSTRACT:
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing hi-or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.

REFERENCES:
patent: 4259472 (1981-03-01), Chatths et al.

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