Calcification-resistant materials and methods of making same thr

Details Calcification-resistant materials and methods of making same thr Calcification-resistant materials and methods of making same thr

1994-11-28

1997-10-21

Caldarola, Glenn A.

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

8 9418, 8 9419, 8 9428, 623 1, 623 2, 623 3, 623 11, 623 12, 623 66, C14H 300, A61F 202

Patent

active

056791127

ABSTRACT:
Bioprosthetic materials, either natural or synthetic, are treated with trivalent iron cations, or salts, to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve leaflets, bovine pericardium, aortic homografts, biocompatible elastomers, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Simple incubation of the natural bioprosthetic materials in an iron ion-containing solution, such as aqueous FeCl.sub.3, particularly with the addition of an anticalcification agent, such as a diphosphonate, prior to implantation has been found to inhibit calcification of the biomaterial over a prolonged period, and to do so without adverse side effects. Incorporation of an iron-containing compound, with or without an additional anticalcification agent, into the formulation for polymers, such as polyurethane, has also been found to inhibit calcification with no adverse side effects.

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