Calcification-resistant bioprosthetic tissue and methods of maki

Details Calcification-resistant bioprosthetic tissue and methods of maki Calcification-resistant bioprosthetic tissue and methods of maki

1995-06-07

1997-10-07

Diamond, Alan D.

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

623 1, 623 2, 623 3, 623 4, 623 7, 623 9, 623 10, 623 11, 623 12, 623 13, 623 14, A61F 202

Patent

active

056742983

ABSTRACT:
Naturally-derived bioprosthetic materials are treated with epoxide crosslinking agents. In some embodiments, the tissue is crosslinked with low molecular weight epoxides in aqueous solutions at high pH levels. In other embodiments, the tissue is crosslinked at physiologic pH levels with epoxide crosslinking agents catalyzed with tertiary or quaternary amines, such as Tris or imidazole. In an advantageous embodiment, bioprosthetic tissue is crosslinked and derivatized with an anticalcification agent, such as a polyphosphonate anticalcification agent, using a polyphosphonate:polyepoxide monoadduct.

REFERENCES:
patent: 4282322 (1981-08-01), Kahan et al.
patent: 4283494 (1981-08-01), Kokusho et al.
patent: 4446122 (1984-05-01), Chu et al.
patent: 4690973 (1987-09-01), Naishiki et al.
patent: 4976733 (1990-12-01), Giradot
patent: 5080670 (1992-01-01), Imamura et al.
patent: 5296583 (1994-03-01), Levy
patent: 5314874 (1994-05-01), Miyata et al.
patent: 5436291 (1995-07-01), Levy et al.

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