Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-30
1999-02-16
Wilson, James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 256, 536 262, 536 2621, 536 2622, 536 2671, 53612313, 536124, 536127, C07H 100, C07H 2100
Patent
active
058722432
ABSTRACT:
The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD.sup.+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.
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Aarhus Robert
Gee Kyle R.
Graeff Richard M.
Haugland Richard P.
Lee Hon Cheung
Helfenstein Allegra J.
Molecular Probes, Inc.
Skaugset Anton E.
The Regents of the University of Minnesota
Wilson James O.
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